Bardoxolone methyl
Product Detail
Product Tags
| Pack Saizi | Kuwanikwa | Mutengo (USD) |
| 1g | Mudura | 300 |
| 5g | Mudura | 1200 |
| 10g | Mudura | 2000 |
| Mamwe Saizi | Wana MaQuotes | Wana MaQuotes |
Chemical Name:
(4aS,6aR,6bS,8aR,12aS,14aR,14bS)-methyl 11-cyano-2,2,6a,6b,9,9,12a-heptamethyl-10,14-dioxo-1,2,3,4 ,4a,5,6,6a,6b,7,8,8a,9,10,12a,14,14a,14b-octadecahydropicene-4a-carboxylate
SMILES Kodhi:
O=C([C@]1(CC[C@@]2(C)[C@]3(C)CCC4C(C)(C)C(C(C#N)=C[C@]4 (C)C3=C5)=O)CCC(C)(C)C[C@]1([H])[C@@]2([H])C5=O)OC
InChi Code:
InChI=1S/C32H43NO4/c1-27(2)11-13-32(26(36)37-8)14-12-31(7)24(20(32)17-27)21(34)15- 23-29(5)16-19(18-33)25(35)28(3,4)22(29)9-10-30(23,31)6/h15-16,20,22,24H, 9-14,17H2,1-8H3/t20-,22?,24+,29+,30-,31-,32+/m1/s1
InChi Key:
WPTTVJLTNAWYAO-OROHISIGSA-N
Keyword:
Bardoxolone methyl, RTA-402, RTA 402, RTA402, NSC-713200, TP-155C, Methyl-CDDO, MethylCDDO, Methyl CDDO, CDDO methyl ester, 218600-53-4
Solubility:Soluble muDMSO
Kuchengeta:0 - 4 ° C kwenguva pfupi (mazuva kusvika mavhiki), kana -20 ° C kwenguva refu (mwedzi)
Tsanangudzo:
The synthetic oleanane triterpenoid CDDO (Item No. 81035) inonzi Nrf2 activator inodzivisa kupararira uye inokonzera kusiyanisa uye apoptosis mumasero akasiyana-siyana ekenza. Iyo C-28 methyl ester yeCDDO (CDDO methyl ester) inovhara cellular synthesis ye inducible nitric oxide synthase (iNOS) uye inducible COX-2 muINF-γ-activated mouse macrophages ane IC50 kukosha kwe0.11 nM. Inokonzera apoptosis, inokonzera kusiyanisa, uye inhibits mhinduro yekuvhiringidza mumasero akasiyana-siyana emarara kuburikidza nekudzivisa IκBα kinase / NF-κB kuisa chiratidzo. CDDO methyl ester ine yakasimba antidiabetic chiitiko, ichideredza proinflammatory cytokine kutaura mune yakakwira mafuta kudya-yakadyiswa mhando 2 diabetic mbeva uye muLeprdb/db mbeva uye inokonzeresa AMP-activated protein kinase uye LKB1 activation mumhasuru uye chiropa.
Chinangwa: NF-kB
