GSK2256098
Product Detail
Product Tags
| Pack Saizi | Kuwanikwa | Mutengo (USD) |
| 100mg | Mudura | 450 |
| 1g | Mudura | 2000 |
| Mamwe Saizi | Wana MaQuotes | Wana MaQuotes |
Chemical Name:
2-((5-chloro-2-((1-isopropyl-3-methyl-1H-pyrazol-5-yl)amino)pyridin-4-yl)amino)-N-methoxybenzamide
SMILES Kodhi:
CC1=NN(C(=C1)NC2=NC=C(C(=C2)NC3=CC=CC=C3C(=O)NOC)Cl)C(C)C
InChi Code:
InChI=1S/C20H23ClN6O2/c1-12(2)27-19(9-13(3)25-27)24-18-10-17(15(21)11-22-18)23-16-8- 6-5-7-14(16)20(28)26-29-4/h5-12H,1-4H3,(H,26,28)(H2,22,23,24)
InChi Key:
BVAHPPKGOOJSPU-UHFFFAOYSA-N
Keyword:
GSK2256098, GSK-2256098, GSK 2256098, GTPL7939, GTPL 7939, GTPL-7939, 1224887-10-8
Solubility:Soluble muDMSO
Kuchengeta:0 - 4 ° C kwenguva pfupi (mazuva kusvika mavhiki), kana -20 ° C kwenguva refu (mwedzi).
Tsanangudzo:
GSK2256098, inozivikanwawo seGTPL7939, is focal adhesion kinase-1 (FAK) inhibitor ine zvinogona antiangiogenic uye antineoplastic zviitiko. FAK inhibitor GSK2256098 inhibits FAK, iyo inogona kudzivirira iyo integrin-mediated activation yeanoverengeka yakadzika masaini transduction nzira, kusanganisira ERK, JNK/MAPK uye PI3K/Akt, nokudaro ichivharira bundu cell migration, kuwanda uye kurarama, uye bundu angiogenesis. Iyo tyrosine kinase FAK inowanzoitwa nekusungirirwa kune integrins mune extracellular matrix (ECM) asi inogona kukwidziridzwa uye inogadziriswa mumhando dzakasiyana dzebundu cell.
Chinangwa: FAK