Batefenterol
Product Detail
Product Tags
| Pack Saizi | Kuwanikwa | Mutengo (USD) |
| 50mg | Mudura | 200 |
| 250mg | Mudura | 600 |
| 500mg | Mudura | 900 |
| 1g | Mudura | 1400 |
| Mamwe Saizi | Wana MaQuotes | Wana MaQuotes |
Chemical Name:
"(R)-1-(3-((2-chloro-4-(((2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl)amino) methyl)-5-methoxyphenyl)amino)-3-oxopropyl)piperidin-4-yl [1,1'-biphenyl]-2-ylcarbamate Batefenterol Succinate"
SMILES Kodhi:
O=C(OC1CCN(CCC(NC2=CC(OC)=C(CNC[C@H](O)C3=CC=C(O)C4=C3C=CC(N4)=O)C=C2Cl)= O)CC1)NC5=CC=CC=C5C6=CC=CC=C6
InChi Code:
InChI=1S/C40H42ClN5O7/c1-52-36-22-33(31(41)21-26(36)23-42-24-35(48)29-11-13-34(47)39-30( 29)12-14-37(49)45-39)43-38(50)17-20-46-18-15-27(16-19-46)53-40(51)44-32-10- 6-5-9-28(32)25-7-3-2-4-8-25/h2-14,21-22,27,35,42,47-48H,15-20,23-24H2, 1H3,(H,43,50)(H,44,51)(H,45,49)/t35-/m0/s1
InChi Key:
URWYQGVSPQJGGB-DHUJRADRSA-N
Keyword:
Batefenterol, TD-5959, GSK961081, 743461-65-6, GSK-961081, GSK 961081, TD5959, TD 5959, 743461-65-6
Solubility:Soluble muDMSO
Kuchengeta:0 - 4 ° C kwenguva pfupi (mazuva kusvika mavhiki), kana -20 ° C kwenguva refu (mwedzi)
Tsanangudzo:
Batefenterol muscarinic antagonist uye β2-adrenergic receptor (β2-AR) agonist (Kis = 1.4, 1.3, uye 3.7 nM, yehM2, hM3, uye hβ2-AR, maererano ne radioligand inosunga assay). Batefenterol inoratidza simba hβ2-AR agonist basa (EC50 = 0.29 nM) ine 440- uye 320-fold functional selectivity pamusoro pehβ1- uye hβ3-ARs, maererano.1 Batefenterol inokonzera kusununguka kwemhasuru yakatsetseka (EC50 = 11 nM) mune imwe nzvimbo yenguruve yeguinea tishu uye inhibits bronchoconstrictor mhinduro muguinea pig bronchoprotection assay (ED50 = 6.4 µg / mL). Magadzirirwo ane batefenterol ari mukiriniki miedzo yekurapa chisingaperi chinobstructive pulmonary chirwere (COPD).
Chinangwa: β2-adrenoceptor
