PQR530
Fa'amatalaga Oloa
Faailoga o oloa
| Tele o le afifi | Avanoa | Tau (USD) |
| 100mg | E tele | 500 |
| 500mg | E tele | 800 |
| 1g | E tele | 1200 |
| Tele Tele | Maua Upusii | Maua Upusii |
Igoa vaila'au:
(S)-4-(difluoromethyl)-5-(4-(3-methylmorpholino)-6-morpholino-1,3,5-triazin-2-yl)pyridin-2-amine
SMILES Code:
NC1=NC=C(C2=NC(N3[C@@H](C)COCC3)=NC(N4CCOCC4)=N2)C(C(F)F)=C1
InChi Code:
InChI=1S/C18H23F2N7O2/c1-11-10-29-7-4-27(11)18-24-16(13-9-22-14(21)8-12(13)15(19)20) 23-17(25-18)26-2-5-28-6-3-26/h8-9,11,15H,2-7,10H2,1H3,(H2,21,22)/t11-/m0 /s1
InChi Key:
SYKBZXMKAPICSO-NSHDSACASA-N
upu autu:
PQR530, PQR-530, PQR 530, 1927857-61-1
Solubility:Solu i le DMSO
Teuina:0 - 4°C mo taimi pupuu (aso i vaiaso), poo le -20°C mo taimi uumi (masina).
Fa'amatalaga:
PQR530 o se fa'atosina lua pan-PI3K/mTORC1/2 sili ona malosi. O le PQR530 na te taofia le protein kinase B (PKB, pSer473) ma le ribosomal protein S6 (pS6, pSer235/236) phosphorylation ma le IC50 o le 0.07 μM. O le PQR530 na faʻaalia ai le filifilia lelei i luga o le lautele lautele o kinases, faʻapea foʻi ma le sili atu le filifilia faʻatasi ai ma enzymes e le fesoʻotaʻi faʻafeiloaʻi ma laina ion. E le gata i lea, o le PQR530 na faʻaalia le malosi i totonu o se laulau o laina sela o le kanesa e 44 (NTRC OncolinesTM) e puipuia ai le tuputupu aʻe o sela o le kanesa (o lona uiga taua mo GI50 o le 426 nM). O le fa'aogaina tautala ole PQR530 i isumu na maua ai le fua fa'atatau o le PK ma fa'aalia ai le lelei ole fa'aogaina ole gutu ma le fa'aogaina lelei ole fai'ai.
Sini: PI3K/mTOR
