BLU-667

Igoa vaila'au:

(1s,4R)-N-((S)-1-(4-(4-fluoro-1H-pyrazol-1-yl)phenyl)ethyl)-1-methoxy-4-(4-methyl-6-( (5-methyl-1H-pyrazol-3-yl)amino)pyrimidin-2-yl)cyclohexane-1-carboxamide

SMILES Code:

CC1=NC([C@@H]2CC[C@](C(N[C@@H](C)C3=CC=C(N4N=CC(F)=C4)C=C3)=O) (OC)CC2)=NC(NC5=NNC(C)=C5)=C1

InChi Code:

InChI=1S/C28H33FN8O2/c1-17-13-24(33-25-14-18(2)35-36-25)34-26(31-17)21-9-11-28(39-4, 12-10-21)27(38)32-19(3)20-5-7-23(8-6-20)37-16-22(29)15-30-37/h5-8,13- 16,19,21H,9-12H2,1-4H3,(H,32,38)(H2,31,33,34,35,36)/t19-,21-,28+/m0/s1

InChi Key:

HUQPYQIGHTXBNW-BDHWGLMFSA-N

upu autu:

BLU-667; BLU 667; BLU667

Solubility:DMSO

Teuina: 

Fa'amatalaga:

O le BLU-667 o se fa'atosina malosi ma le filifilia o suiga ole RET, fusuaga, ma va'aiga mutants fa'asagatau. O fusuaga a le RET o fa'auluuluga autu ia o le tele o kanesa, e aofia ai le kanesa o le mama ma le thyroid, ma o la matou su'esu'ega e fa'ailoa mai ai o le RET e iai fo'i se sao taua i nisi o kanesa ma le susu. E ala i le tulituliloaina i le taimi lava e tasi le aveta'avale muamua ma vavalo mutants tetee e mafua ai le le mautonu o sela o le kanesa i togafitiga ma fualaau ua faamaonia nei,

Sini: RET