BI-847325
Fa'amatalaga Oloa
Faailoga o oloa
| Tele o le afifi | Avanoa | Tau (USD) |
| 100mg | E tele | 400 |
| 500mg | E tele | 950 |
| 1g | E tele | 1400 |
| Tele Tele | Maua Upusii | Maua Upusii |
Igoa vaila'au:
(Z)-3-(3-(((4-((dimethylamino)methyl)phenyl)amino)(phenyl)methylene)-2-oxoindolin-6-yl)-N-ethylpropiolamide
SMILES Code:
O=C(NCC)C#CC1=CC(NC/2=O)=C(C=C1)C2=C(NC3=CC=C(CN(C)C)C=C3)/C4=CC= CC=C4
InChi Code:
InChI=1S/C29H28N4O2/c1-4-30-26(34)17-13-20-12-16-24-25(18-20)32-29(35)27(24)28(22-8- 6-5-7-9-22)31-23-14-10-21(11-15-23)19-33(2)3/h5-12,14-16,18,31H,4,19H2, 1-3H3,(H,30,34)(H,32,35)/b28-27-
InChi Key:
FLBNLJLONKAPLR-DQSJHHFOSA-N
upu autu:
BI-847325, BI847325, BI 847325, 1207293-36-4
Solubility:Solu i le DMSO
Teuina:0 - 4°C mo taimi pupuu (aso i vaiaso), po'o le -20°C mo taimi uumi (masina)
Fa'amatalaga:
O le BI-847325 o se faʻaoga lua MEK / Aurora kinase inhibitor ma IC50 tau o 3, 25, 15, 25, ma 4 nM mo X. laevis Aurora B, tagata Aurora A ma Aurora C, ma tagata MEK1 ma MEK2, faasologa. E mafai ona faʻalavelaveina le tuputupu aʻe ma le ola o togafitiga-naive ma vailaʻau-faʻasaʻo laina sela melanoma, faʻaitiitia le faʻaalia o MEK ma Mcl-1 aʻo faʻateleina le faʻaaliga o le pro-apoptotic protein Bim. I le 70 mg/kg, BI-847325 fa'aoso apoptosis i togafitiga-naive ma fualaau faasaina xenografted melanoma i vivo.
Sini: MEK/Aurora
