MSC2530818
Fa'amatalaga Oloa
Faailoga o oloa
| Tele o le afifi | Avanoa | Tau (USD) |
| 100mg | E tele | 400 |
| Tele Tele | Maua Upusii | Maua Upusii |
Igoa vaila'au:
[(2S)-2-(4-Chlorophenyl)pyrrolidin-1-yl]-(3-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl)methanone
SMILES Code:
O=C(N1[C@H](C2=CC=C(Cl)C=C2)CCC1)C3=CN=C(NN=C4C)C4=C3
InChi Code:
InChI=1S/C18H17ClN4O/c1-11-15-9-13(10-20-17(15)22-21-11)18(24)23-8-2-3-16 (23)12-4-6-14(19)7-5-12/h4-7,9-10,16H,2-3,8H2,1H3,(H,20,21,22)/t16-/ m0/s1
InChi Key:
ODRITQGYYWHQGM-INIZCTEOSA-N
upu autu:
MSC2530818, MSC-2530818, MSC 2530818, 1883423-59-3
Solubility:Solu i le DMSO
Teuina:0 - 4°C mo taimi pupuu (aso i vaiaso), poo le -20°C mo taimi uumi (masina).
Fa'amatalaga:
MSC2530818 o le malosi, Filifilia, ma le tautala le CDK8 Inhibitor ma CDK8 IC50 = 2.6 nM; Va'aiga PK tagata: Cl ~ 0.14 L/H/Kg; t1/2 ~ 2.4h; F > 75%. O le MSC2530818 e fa'aalia ai le filifilia lelei o le kinase, biochemical ma cellular potency, microsomal stability, ma e mafai ona tu'u gutu. MSC2530818 fa'aalia le agava'a talafeagai ma le filifilia e aga'i i luma ile fa'ata'ita'iga i vivo aoga ma su'esu'ega saogalemu.
Sini: CDK
