BS-181

Igoa vaila'au:

N5-(6-aminohexyl)-N7-benzyl-3-isopropylpyrazolo[1,5-a]pyrimidine-5,7-diamine hydrochloride

SMILES Code:

CC(C1=C2N=C(NCCCCCCN)C=C(NCC3=CC=CC=C3)N2N=C1)C.[H]Cl

InChi Code:

InChI=1S/C22H32N6.ClH/c1-17(2)19-16-26-28-21(25-15-18-10-6-5-7-11-18)14-20(27-22( 19)28 )24-13-9-4-3-8-12-23;/h5-7,10-11,14,16-17,25H,3-4,8-9,12-13,15,23H2, 1-2H3,(H,24,27);1H

InChi Key:

NVIJWMOQODWNFN-UHFFFAOYSA-N

upu autu:

Solubility: 

Teuina: 

Fa'amatalaga:

O le BS-181 ose CDK e sili ona filifilia mo le CDK7 ma le IC(50) o le 21 nmol/L. O suʻesuʻega o isi CDKs faʻapea foʻi ma isi 69 kinases na faʻaalia ai naʻo le BS-181 na te taofia le CDK2 i faʻamaʻi maualalo ifo i le 1 micromol / L, ma le CDK2 o loʻo taofia 35-faʻaitiitia le malosi (IC (50) 880 nmol / L) nai lo CDK7. I sela MCF-7, BS-181 taofia le phosphorylation o le CDK7 substrates, siitia le taamilosaga o le puʻeina ma apoptosis e taofia ai le tuputupu aʻe o laina sela o le kanesa, ma faʻaalia aʻafiaga antitumor i vivo.

Sini: CDK7