Voruciclib

Igoa vaila'au:

2-(2-Chloro-4-(trifluoromethyl)phenyl) -5,7-dihydroxy-8-((2R,3S) -2-(hydroxymethyl) -1-methylpyrrolidin-3-yl) -4H-1-benzopyran -4-tasi

SMILES Code:

O=C1C=C(C2=CC=C(C(F)(F)F)C=C2Cl)OC3=C([C@H]4[C@H](CO)N(C)CC4)C (O)=CC(O)=C13

InChi Code:

InChI=1S/C22H19ClF3NO5/c1-27-5-4-12(14(27)9-28)19-15(29)7-16(30)20-17(31)8-18(32-21( 1 9)20)11-3-2-10(6-13(11)23)22(24,25)26/h2-3,6-8,12,14,28-30H,4-5,9H2, 1H3/t12-,14+/m1/s1

InChi Key:

MRPGRAKIAJJGMM-OCCSQVGLSA-N

upu autu:

P1446A05, P1446A-05, P1446A 05, Voruciclib

Solubility: 

Teuina: 

Fa'amatalaga:

Voruciclib, lea e lauiloa foi o le P1446A-05, o se polotini kinase inhibitor faapitoa mo le cyclin-faalagolago kinase 4 (CDK4) ma gaioiga antineoplastic gafatia. O le CDK4 inhibitor P1446A-05 fa'apitoa e fa'alavelaveina le CDK4-mediated G1-S vaega suiga, pu'eina le uila uila ma fa'alavelaveina le tuputupu a'e o le kanesa. O le serine / threonine kinase CDK4 o loʻo maua i totonu o se faʻalavelave faʻatasi ma D-ituaiga G1 cyclins ma o le kinase muamua lea e faʻagaoioia ile mitogenic stimulation, tuʻuina atu sela mai se tulaga quiescent i le G1 / S tuputupu aʻe uila laasaga; CDK-cyclin complexes ua faʻaalia e phosphorylate le retinoblastoma (Rb) transcription factor i le amataga o le G1, faʻateʻaina le histone deacetylase (HDAC) ma poloka le faʻasaʻoina o tusitusiga.

Sini: CDK4