THZ2
Fa'amatalaga Oloa
Faailoga o oloa
| Tele o le afifi | Avanoa | Tau (USD) |
| 100mg | E tele | 500 |
| 500mg | E tele | 800 |
| 1g | E tele | 1200 |
| Tele Tele | Maua Upusii | Maua Upusii |
Igoa vaila'au:
N-[3-[[5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl]amino]phenyl]-3-[[(E)-4-(dimethylamino)ae-2- enoyl]amino]benzamide
SMILES Code:
O=C(NC1=CC=CC(NC2=NC=C(Cl)C(C3=CNC4=C3C=CC=C4)=N2)=C1)C5=CC=CC(NC(/C=C/CN) (C)C)=O)=C5
InChi Code:
InChI=1S/C31H28ClN7O2/c1-39(2)15-7-14-28(40)35-21-9-5-8-20(16-21)30(41)36-22-10-6- 11-23(17-22)37-31-34-19-26(32)29(38-31)25-18-33-27-13-4-3-12-24(25)27/h3- 14,16-19,33H,15H2,1-2H3,(H,35,40)(H,36,41)(H,34,37,38)/b14-7+
InChi Key:
FONRCZUZCHXWBD-VGOFMYFVSA-N
upu autu:
THZ-2, THZ 2, THZ2, 1604810-84-5
Solubility:Solu i le DMSO
Teuina:0 - 4°C mo taimi pupuu (aso i vaiaso), poo le -20°C mo taimi uumi (masina).
Fa'amatalaga:
THZ2, o se analog o le THZ1, faatasi ai ma le gafatia e togafitia ai le kanesa o le susu Tolu-negative (TNBC), o se inhibitor CDK7 malosi ma filifili lea e manumalo ai i le le mautonu o le THZ1 i vivo. IC50: CDK7= 13.9 nM; TNBC sela= 10 nM
Sini: CDK
