Riviciclib

Igoa vaila'au:

2-(2-chlorophenyl) -5,7-dihydroxy-8-((2R,3S) -2-(hydroxymethyl) -1-methylpyrrolidin-3-yl) -4H-chromen-4-one hydrochloride

SMILES Code:

O=C1C=C(C2=CC=CC=C2Cl)OC3=C1C(O)=CC(O)=C3[C@H]4[C@H](CO)N(C)CC4.[H] Cl

InChi Code:

InChI=1S/C21H20ClNO5.ClH/c1-23-7-6-12(14(23)10-24)19-15(25)8-16(26)20-17(27)9-18(28- 21(19)20)11-4-2-3-5-13(11)22;/h2-5,8-9,12,14,24-26H,6-7,10H2,1H3;1H/t12 -,14+;/m1./s1

InChi Key:

OOVTUOCTLAERQD-OJMBIDBESA-N

upu autu:

P276-00; P-276-00; P 276-00; P-27600; P 27600; P 27600; Riviciclib, Riviciclib HCl

Solubility: 

Teuina: 

Fa'amatalaga:

Riviciclib, lea e lauiloa foi o le P276-00, o se flavone ma cyclin dependent kinase (CDK) inhibitor ma gaioiga antineoplastic gafatia. P276-00 filifili faʻatasi ma faʻalavelave Cdk4 / cyclin D1, Cdk1 / cyclin B ma Cdk9 / cyclin T1, serine / threonine kinases o loʻo taʻalo i matafaioi taua i le faatonutonuina o le taamilosaga o le cell ma le faʻalauteleina o le telefoni. O le faʻasaina o nei kinases e taʻitaʻia ai le puʻeina o le taamilosaga i le taimi o le suiga o le G1 / S, ma oʻo atu ai i le faʻaogaina o le apoptosis, ma le faʻalavelaveina o le faʻateleina o le tumo.

Sini: CDK