GLPG0187

Igoa vaila'au:

(S)-3-((2,5-dimethyl-6-(4-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)piperidin-1-yl)pyrimidin-4- yl)amino)-2-((4-methoxyphenyl)sulfonamido)propanoic acid

SMILES Code:

O=C(O)[C@H](CNC1=NC(C)=NC(N2CCC(C3=NC4=C(CCCN4)C=C3)CC2)=C1C)NS(=O)(C5=CC= C(OC)C=C5)=O

InChi Code:

InChI=1S/C29H37N7O5S/c1-18-26(31-17-25(29(37)38)35-42(39,40)23-9-7-22(41-3)8-10-23) 32-19(2)33-28(18)36-15-12-20(13) -16-36)24-11-6-21-5-4-14-30-27(21)34-24/h6-11,20,25,35H,4-5,12-17H2,1-3H3 ,(H,30,34)(H,37,38)(H,31,32,33)/t25-/m0/s1

InChi Key:

CXHCNOMGODVIKB-VWLOTQADSA-N

upu autu:

GLPG0187, GLPG-0187, GLPG 0187, 1320346-97-1

Solubility:Solu i le DMSO

Teuina:0 - 4°C mo taimi pupuu (aso i vaiaso), poo le -20°C mo taimi uumi (masina).

Fa'amatalaga:

I se suʻega faʻamalosi, GLPG0187 o loʻo faʻaalia le filifilia mo le tele o RGD integrin receptors ma IC50s o 1.3, 3.7, 2.0, 1.4, 1.2, 7.7 nM mo αvβ1, αvβ3, αvβ5, αvβ6, αvβ8, ma αvβ8. GLPG0187 o se faʻalavelave malosi o le faʻaogaina o ponaivi osteoclastic ma le angiogenesis. Togafitiga faʻatasi ma le GLPG0187 dose-faʻalagolago e faʻateleina ai le E-cadherin / vimentin ratio, faʻaliliuina sela o se epithelial, sessile phenotype sili atu. GLPG0187 fua fa'atatau-fa'alagolago fa'aitiitiina le tele o le aldehyde dehydrogenase maualuga subpopulation o sela o le kanesa prostate [1]. O togafitiga GLPG0187 e maua ai le fa'ata'amilomilo ma fa'apipi'i. O le GLPG0187 o loʻo faʻaalia ai se faʻaitiitiga faʻalagolago tele i le femalagaiga o sela tumo. GLPG0187 i faʻasalalauga uma e faʻaitiitia ai le faʻateleina o le cell [2].

Sini: αvβ1