IT-901

Igoa vaila'au:

5-[(2,4-Dimethoxy-1-naphthalenyl)methylene]dihydro-2-thioxo-4,6(1H,5H)-pyrimidinedione

SMILES Code:

O=C(/C(C(N1)=O)=CC2=C3C=CC=CC3=C(OC)C=C2OC)NC1=S

InChi Code:

InChI=1S/C17H14N2O4S/c1-22-13-8-14(23-2)11(9-5-3-4-6-10(9)13)7-12-15(20)18-17( 24)19-16(12)21/h3-8H,1-2H3,(H2,18,19,20,21,24)

InChi Key:

JHOPCCOYRKEHQU-UHFFFAOYSA-N

upu autu:

IT-901, IT901, IT 901, 1584121-99-2

Solubility:Solu i le DMSO

Teuina:0 - 4°C mo taimi pupuu (aso i vaiaso), poo le -20°C mo taimi uumi (masina).

Fa'amatalaga:

"IT-901 o se c-Rel Inhibitor lea e fa'afesoota'i mea fa'ama'i fa'ama'i i le hematologic malignancies e ala i le polokaina o le NF-κB-Controlled Oxidative Stress Responses. IT-901 mamana fa'alavelaveina le NF-κB subunit c-Rel. IT-901 taofiofia fusi-versus- faʻamaʻi faʻamaʻi aʻo faʻasaoina gaioiga faʻasolosolo-versus-lymphoma i le taimi o le faʻaogaina o le allogeneic suʻesuʻega a le IT-901 mo le togafitiga o le lymphoma sela B-tagata na faʻaalia ai le antitumor i vitro ma in vivo e aunoa ma le faʻatapulaʻaina o le NF-κB-faʻalagolago i le lymphoma. 901 e leʻi faʻaalia le faʻateleina o ituaiga o le okesene faʻaalia i leukocytes masani, e faʻaalia ai lona kanesa filifilia o le IT-901 o se vailaʻau faʻapitoa e togafitia ai le tino o le tagata ma faʻaleleia le faʻamaʻi faʻamaʻi.

Sini: NF-kB