RGX-104 HCl

Igoa vaila'au:

(R)-2-[3-[3-[[2-Chloro-3-(trifluoromethyl)benzyl](2,2-diphenylethyl)amino]-3-methylpropoxy]phenyl]acetic acid hydrochloride

SMILES Code:

O=C(O)CC1=CC=CC(OCC[C@H](N(CC2=CC=CC(C(F)(F)F)=C2Cl)CC(C3=CC=CC=C3)C4 =CC=CC=C4)C)=C1.[H]Cl

InChi Code:

InChI=1S/C34H33ClF3NO3.ClH/c1-24(18-19-42-29-16-8-10-25(20-29)21-32(40)41)39(22-28-15-9- 17-31(33(28)35)34(36 ,37)38)23-30(26-11-4-2-5-12-26)27-13-6-3-7-14-27;/h2-17,20,24,30H,18- 19,21-23H2,1H3,(H,40,41);1H/t24-;/m1./s1

InChi Key:

LCMIYQOJZLRHTO-GJFSDDNBSA-N

upu autu:

RGX-104 HCl, RGX-104, RGX104, RGX 104, 610318-03-1

Solubility:Solu i le DMSO

Teuina:0 - 4°C mo taimi pupuu (aso i vaiaso), poo le -20°C mo taimi uumi (masina).

Fa'amatalaga:

O le RGX-104 o le ate X receptor beta agonist e mafai ona faʻaogaina le immunomodulating ma gaioiga antineoplastic. I luga o le tautala tautala, RGX-104 filifilia ma fusifusia i le LXRbeta, ma faʻagaoioia ai le LXRbeta-mediated signaling, e oʻo atu ai i le faʻaliliuina o nisi o genes suppressor tumo ma le faʻalaloina o nisi genes promoter tumo. O lenei mea e fa'aagaoioia ai le fa'aaliga o le apolipoprotein E (ApoE), o se polotini e taofia ai le tumo, i sela tumo ma nisi sela puipuia. O le mea lea e fa'aagaoioia ai le fa'aogaina o le tino, e mafua ai le fa'aitiitiga o le immunosuppressive myeloid-derived suppressor cells (MDSCs), sela tumo ma sela endothelial i totonu ole si'osi'omaga o le tumo. Ole mea lea e toe fa'afo'isia ai le puipuiga o le tino, fa'aleleia le tali atu i le tumo ma fa'alavelaveina le fa'ateleina o sela tumo.

Sini: LXRbeta