Vactosertib

Igoa vaila'au:

N-((4-([1,2,4] triazolo [1,5-a] pyridin-6-yl) -5-(6-methylpyridin-2-yl) -1H-imidazol-2-yl)methyl )-2-fluoroaniline

SMILES Code:

FC1=CC=CC=C1NCC2=NC(C3=CN4C(C=C3)=NC=N4)=C(C5=NC(C)=CC=C5)N2

InChi Code:

InChI=1S/C22H18FN7/c1-14-5-4-8-18(27-14)22-21(15-9-10-20-25-13-26-30(20)12-15)28- 19(29-22)11-24-17-7-3-2-6-16(17)23/h2-10,12-13,24H,11H2,1H3,(H,28,29)

InChi Key:

FJCDSQATIJKQKA-UHFFFAOYSA-N

upu autu:

Vactosertib, EW-7197, EW7197, EW 7197, 1352608-82-2

Solubility:Solu i le DMSO

Teuina:0 - 4°C mo taimi pupuu (aso i vaiaso), po'o le -20°C mo taimi uumi (masina)

Fa'amatalaga:

Vactosertib, lea e taʻua foi o le EW-7197 o se inhibitor malosi ALK5. EW-7197 faʻaalia le malosi i vivo anti-metastatic gaioiga, faʻaalia lona gafatia mo le faʻaaogaina o se togafitiga faʻamaʻi-kanesa. EW-7197 fa'alavelave TGF-β/Smad fa'ailoga. EW-7197 ua soloia le TGF-β1-fa'aosoina le femalaga'iga ma osofa'iga. EW-7197 fa'asaina le kanesa o le susu i le mama.EW-7197 fa'aumiina le ola ole BALB/c 4T1 isumu e ala ile taofia ole EMT. EW-7197 taofia metastasis ma faʻaleleia le gaioiga o cytotoxic T lymphocytes (CTLs) i 4T1 orthotopic faʻapipiʻiina isumu.

Sini: ALK