ND-630
Fa'amatalaga Oloa
Faailoga o oloa
| Tele o le afifi | Avanoa | Tau (USD) |
| 10mg | E tele | 300 |
| 50mg | E tele | 500 |
| 100mg | E tele | 800 |
| Tele Tele | Maua Upusii | Maua Upusii |
Igoa vaila'au:
(R)-2-(1-(2-(2-methoxyphenyl)-2-((tetrahydro-2H-pyran-4-yl)oxy)ethyl)-5-methyl-6-(oxazol-2-yl) -2,4-dioxo-1,2-dihydrothieno[2,3-d]pyrimidin-3(4H)-yl)-2-methylpropanamide
SMILES Code:
O=C(N)C(C)(C)N(C(N(C[C@@H](C1=CC=CC=C1OC)OC2CCOCC2)C3=C4C(C)=C(C5=NC= CO5)S3)=O)C4=O
InChi Code:
InChI=1S/C28H31N3O8S/c1-16-21-24(32)31(28(2,3)26(33)34)27(35)30(25(21)40-22(16)23-29- 11-14-38-23)15-20(39-17-9-12-37-13-10-17)18-7-5-6-8-19(18)36-4/h5-8, 11,14,17,20H,9-10,12-13,15H2,1-4H3,(H,33,34)/t20-/m0/s1
InChi Key:
ZZWWXIBKLBMSCS-FQEVSTJZSA-N
upu autu:
ND-630, ND630, ND 630, GS-0976, GS0976, GS 0976, NDI-010976, NDI010976, NDI 010976, Firsocostat, 1434635-54-7
Solubility:Solu i le DMSO
Teuina:0 - 4°C mo taimi pupuu (aso i vaiaso), poo le -20°C mo taimi uumi (masina).
Fa'amatalaga:
O le ND-630 e taofia ai le hACC1 (IC50=2.1±0.2 nM) ma le hACC2 (IC50=6.1±0.8 nM). O le fa'alavelave e mafai ona toe fa'afo'i ma fa'apitoa mo le ACC. O le ND-630 e taofia ai le gaioiga o le ACC e ala i le fegalegaleai i totonu o le phosphopeptide-acceptor ma le dimerization site o le enzyme e puipuia ai le faʻamaʻi. O le ND-630 e taofia ai le faʻaogaina o le gaʻo gaʻo ma le EC50 o le 66 nM i le HepG2 sela e aunoa ma le suia o le numera atoa o le cell, faʻaogaina o le protein, ma le tuʻufaʻatasia o le acetate i le cholesterol [1].
Sini: ACC
