Bardoxolone
Fa'amatalaga Oloa
Faailoga o oloa
Tele o le afifi | Avanoa | Tau (USD) |
100mg | E tele | 300 |
500mg | E tele | 1000 |
1g | E tele | 1700 |
Tele Tele | Maua Upusii | Maua Upusii |
Igoa vaila'au:
(4aS,6aR,6bS,8aR,12aS,14aR,14bS)-11-cyano-2,2,6a,6b,9,9,12a-heptamethyl-10,14-diox o-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,12a,14,14a,14b-octadecahydropicene-4a-carboxylic acid
SMILES Code:
CC(C)([C@](CC[C@@]([C@@]1(CC[C@]2(CCC(C)(C[C@]2([C@]13[H) ])[H])C)C(O)=O)C)4C)5[H])C(C(C#N)=C[C@]5(C)C4=CC3=O)=O
InChi Code:
InChI=1S/C31H41NO4/c1-26(2)10-12-31(25(35)36)13-11-30(7)23(19(31)16-26)20(33)14-22- 28(5)15-18(17-32)24(34 )27(3,4)21(28)8-9-29(22,30)6/h14-15,19,21,23H,8-13,16H2,1-7H3,(H,35,36) /t19-,21-,23-,28-,29+,30+,31-/m0/s1
InChi Key:
TXGZJQLMVSIZEI-UQMAOPSPSA-N
upu autu:
Bardoxolone, RTA 402, CCDO, RTA-402, RTA402, 218600-44-3
Solubility:Solu i le DMSO
Teuina:0 - 4°C mo taimi pupuu (aso i vaiaso), poo le -20°C mo taimi uumi (masina).
Fa'amatalaga:
O vaega ole fatuga'o mai manuki e togafitia ile Bardoxolone methyl e fa'aalia ai le fa'aitiitia o le fa'aaliga o le porotini megalin e ui lava i fa'aaliga mRNA tutusa i vaega uma. O le fa'aitiitiga va'aia o le fa'aaliga o le porotini megalin e fa'amaonia i su'esu'ega o le densitometry, lea na fa'aalia ai o le pulega o le Bardoxolone methyl na matua fa'aitiitia ai le fa'aaliga o le porotini megalin i le fatuga'o manuki. Bardoxolone methyl administration e le afaina ai le faʻaalia o le porotini o le cubilin i le fatugaʻo poʻo le faʻaaliga mRNA o le cubilin i le fatugaʻo. O le kiliaina o le creatinine i manuki na faʻatonuina Bardoxolone methyl e matua ese lava mai lena i le laina faʻavae ma manu faʻataʻavalevale i le aso 28. A maeʻa le 28 aso o le Bardoxolone methyl administration, urinary albumin-to-creatinine ratios (UACRs), fuafuaina mai le urine 24-itula. aoina, e matua faateleina pe a faatusatusa i latou i manu maua taavale. O le faʻamatalaga, o le UACR e faʻaitiitia ai le 53.3% i manu faʻataʻavalevale ma faʻateleina le 27.9% ile Bardoxolone methyl-treated manuki [3]. O isumu tama C57BL/6J o lo'o tu'u gutu ile BARD ile taimi ole fafaga a le HFD (HFD/BARD), na'o le fafagaina o mea'ai ga'o (HFD), po'o le fafagaina o mea'ai maualalo (LFD) mo le 21 vaiaso. Pe a fa'atusatusa i isumu LFD, o isumu HFD e fa'ailogaina le si'itia o le aofa'i o F4/80 fa'a-pale (+95%; p.<0.001), lea e puipuia lelei e le BARD (−50%; i<0.01). E faapena foi, o le numera o F4/80 interstitial macrophages e matua maualuga lava i isumu HFD e 98% (p<0.001) fa'atusatusa i isumu LFD ma le 32% (i<0.01) fa'atusatusa i isumu HFD/BARD[4].
Sini: Nrf-2