OTS964
Fa'amatalaga Oloa
Faailoga o oloa
| Tele o le afifi | Avanoa | Tau (USD) |
| 1g | E tele | 1750 |
| Tele Tele | Maua Upusii | Maua Upusii |
Igoa vaila'au:
(R)-9-(4-(1-(dimethylamino)propan-2-yl)phenyl)-8-hydroxy-6-methylthieno[2,3-c]quinolin-4(5H)-one
SMILES Code:
[H]Cl.O=C1NC2=C(C(C3=CC=C([C@@H](C)CN(C)C)C=C3)=C(O)C=C2C)C4=C1SC =C4
InChi Code:
InChI=1S/C23H24N2O2S.ClH/c1-13-11-18(26)19(16-7-5-15(6-8-16)14(2)12-25(3)4)20-17- 9-10-28-22(17)23(27)24-21(13)20;/h5-11,14,26H,12H2,1-4H3,(H,24,27);1H/t14-; /m0./s1
InChi Key:
YHPWOYBWUWSJDW-UQKRIMTDSA-N
upu autu:
OTS 964, OTS-964, OTS964, 1338545-07-5
Solubility:Solu i le DMSO
Teuina:0 - 4°C mo taimi pupuu (aso i vaiaso), po'o le -20°C mo taimi uumi (masina)
Fa'amatalaga:
O le OTS964 o se fa'alavelave ole lymphokine-activated killer T cell-originated protein kinase (TOPK; IC50 = 28 nM). E poloka faapitoa le cytokinesis, e tau atu i le apoptosis, i le lautele o sela o le kanesa. OTS964 fa'aoso apoptosis o sela o le kanesa mama i le xenografts isumu.
Sini: TOPK
