AZD7507

Igoa vaila'au:

4-(2-fluoro-4-methylanilino)-6-[4-(2-hydroxyethyl)piperazin-1-yl]-7-methoxycinnoline-3-carboxamide

SMILES Code:

O=C(C1=NN=C2C=C(OC)C(N3CCN(CCO)CC3)=CC2=C1NC4=CC=C(C)C=C4F)N

InChi Code:

InChI=1S/C23H27FN6O3/c1-14-3-4-17(16(24)11-14)26-21-15-12-19(30-7-5-29(6-8-30)9- 10-31)20(33-2)13-18(15)27-28-22(21)23(25)32/h3-4,11-13,31H,5-10H2,1-2H3,(H2 ,25,32)(H,26,27)

InChi Key:

CPDGCAFPSYOTGO-UHFFFAOYSA-N

upu autu:

AZD7507; AZD-7507; AZD 7507

Solubility:DMSO

Teuina: 

Fa'amatalaga:

O le AZD7507 o le malosi ma le filifilia o le CSF-1R inhibitor (32 nM cell activity), o le AZD7507 o loʻo manatu o se faʻamoemoega faʻapipiʻi ona o loʻo taofia ai le manaʻoga manaʻomia ma mea tau vailaʻau o le AZ683. E le gata i lea, i se suʻesuʻega telemetry i maile na tuʻuina atu i ai se tui e tasi, e leai se faʻamaʻi cardiovascular, leai se maualuga o le troponin e fesoʻotaʻi ma togafitiga, ma leai se suiga i le ECG.

Sini: CSF-1R