BLU-9931

Igoa vaila'au:

N-(2-((6-(2,6-dichloro-3,5-dimethoxyphenyl)quinazolin-2-yl)amino)-3-methylphenyl)acrylamide

SMILES Code:

C=CC(NC1=CC=CC(C)=C1NC2=NC=C3C=C(C4=C(Cl)C(OC)=CC(OC)=C4Cl)C=CC3=N2)=O

InChi Code:

InChI=1S/C26H22Cl2N4O3/c1-5-21(33)30-18-8-6-7-14(2)25(18)32-26-29-13-16-11-15(9-10- 17(16)31-26)22-23(27)19(34-3)12-20(35-4)24(22)28/h5-13H,1H2,2-4H3,(H,30,33) )(H,29,31,32)

InChi Key:

TXEBNKKOLVBTFK-UHFFFAOYSA-N

upu autu:

BLU-9931, BLU9931, BLU 9931, 1538604-68-0

Solubility:Solu i le DMSO

Teuina:0 - 4°C mo taimi pupuu (aso i vaiaso), poo le -20°C mo taimi uumi (masina).

Fa'amatalaga:

I sela MDA-MB-453, BLU9931 malosi faʻalavelave faʻafefe phosphorylation o le FGFR4 ala faʻailoga. BLU9931 taofia le faʻateleina o laina telefoni HCC e faʻaalia ai le faʻaogaina o le FGFR4 faʻailoga faʻalavelave, e pei o laina telefoni Hep 3B, HUH-7, ma JHH-7, ma EC50 o<1 μM. O le BLU9931 e taofia ai le faʻateleina i laina telefoni feaveaʻi PDX ma se ala faʻailoga FGFR4 e le atoatoa [1]. O le BLU9931 e faʻaosoina ai le paʻu o le tumo i faʻataʻitaʻiga o le carcinoma hepatocellular e faʻaalia ai le faʻaogaina o le ligand / receptor complex e aofia ai le FGF19 / FGFR4 / KLB ma faʻaopoopo i se lisi tuputupu aʻe o sui anti-FGFR4 [2].

Sini: FGFR4