Bardoxolone methyl

Izina ryimiti:

. (4aS, 6aR, 6bS, 8aR, 12aS, 14aR, 14bS) , 4a, 5,6,6a, 6b, 7,8,8a, 9,10,12a, 14,14a, 14b-octadecahydropicene-4a-karubasi

Kode ya SMILES:

O = C ([C @] 1 (CC [C @@] 2 (C) [C @] 3 (C) CCC4C (C) (C) C (C (C # N) = C [C @] 4 (C) C3 = C5) = O) CCC (C) (C) C [C @] 1 ([H]) [C @@] 2 ([H]) C5 = O) OC

InChi Code:

InChI = 1S / C32H43NO4 / c1-27 (2) 11-13-32 (26 (36) 37-8) 14-12-31 (7) 24 (20 (32) 17-27) 21 (34) 15- 23-29 (5) 16-19 (18-33) 25 (35) 28 (3,4) 22 (29) 9-10-30 (23,31) 6 / h15-16,20,22,24H, 9-14,17H2,1-8H3 / t20-, 22 ?, 24 +, 29 +, 30-, 31-, 32 + / m1 / s1

InChi Urufunguzo:

WPTTVJLTNAWYAO-OROHISIGSA-N

Ijambo ryibanze:

Bardoxolone methyl, RTA-402, RTA 402, RTA402, NSC-713200, TP-155C, Methyl-CDDO, MethylCDDO, Methyl CDDO, CDDO methyl ester, 218600-53-4

Gukemura:Gukemura muri DMSO

Ububiko:0 - 4 ° C mugihe gito (iminsi kugeza ibyumweru), cyangwa -20 ° C mugihe kirekire (amezi)

Ibisobanuro:

Sintetike oleanane triterpenoid CDDO (Ingingo nimero 81035) ni Nrf2 ikora ibuza ikwirakwizwa kandi igatera itandukaniro na apoptose mungirangingo zitandukanye za kanseri. C-28 methyl ester ya CDDO (CDDO methyl ester) ihagarika synthesis ya selile ya synthase ya nitric oxyde ya nitric (iNOS) hamwe na COX-2 idasobanutse muri INF-γ-ikora imbeba ya macrophage ifite IC50 ifite agaciro ka 0.11 nM. Itera apoptose, itera itandukaniro, kandi ikabuza kwitabira gutwika ingirabuzimafatizo zitandukanye binyuze mu kubuza ibimenyetso bya IκBα kinase / NF-κB. CDDO methyl ester ifite ibikorwa bya antidiabete ikomeye, igabanya imvugo ya protinflammatory cytokine mumagambo menshi yimirire yagaburiwe nimbeba ya diyabete yo mu bwoko bwa 2 no mu mbeba za Leprdb / db no gukurura poroteyine ikora AMP ikora na LKB1 mumitsi n'umwijima.

Intego: NF-kB