Batefenterol

Izina ryimiti:

"(R) -1- (3 - ((2-chloro-4 - (((2-hydroxy-2- methyl) -5-mikorerexyphenyl) amino) -3-oxopropyl) piperidin-4-yl [1,1'-biphenyl] -2-ylcarbamate Batefenterol Succinate "

Kode ya SMILES:

O = C (OC1CCN (CCC (NC2 = CC (OC) = C) (CNC [C @ H] (O) C3 = CC = C (O) C4 = C3C = CC (N4) = O) C = C2Cl) = O) CC1) NC5 = CC = CC = C5C6 = CC = CC = C6

InChi Code:

InChI = 1S / C40H42ClN5O7 / c1-52-36-22-33 (31 (41) 21-26 (36) 23-42-24-35 (48) 29-11-13-34 (47) 39-30 ( 29) 12-14-37 (49) 45-39) 43-38 (50) 17-20-46-18-15-27 (16-19-46) 53-40 (51) 44-32-10- 6-5-9-28 (32) 25-7-3-2-4-8-25 / h2-14,21-22,27,35,42,47-48H, 15-20,23-24H2, 1H3, (H, 43,50) (H, 44,51) (H, 45,49) / t35- / m0 / s1

InChi Urufunguzo:

URWYQGVSPQJGGB-DHUJRADRSA-N

Ijambo ryibanze:

Batefenterol, TD-5959, GSK961081, 743461-65-6, GSK-961081, GSK 961081, TD5959, TD 5959, 743461-65-6

Gukemura:Gukemura muri DMSO

Ububiko:0 - 4 ° C mugihe gito (iminsi kugeza ibyumweru), cyangwa -20 ° C mugihe kirekire (amezi)

Ibisobanuro:

Batefenterol ni antagonist ya muscarinic na β2-adrenergic reseptor (β2-AR) agonist (Kis = 1.4, 1.3, na 3.7 nM, kuri hM2, hM3, na hβ2-AR, muburyo bwa radioligand ihuza). Batefenterol yerekana ibikorwa bikomeye bya hβ2-AR agoniste (EC50 = 0.29 nM) hamwe na 440- na 320 inshuro zihitamo imikorere ya hβ1- na hβ3-ARs, kimwe.1 Batefenterol itera kuruhura imitsi neza (EC50 = 11 nM) muri tracheal yingurube ya Gineya; tissue kandi ikabuza igisubizo cya bronchoconstrictor muri guinea ingurube bronchoprotection assay (ED50 = 6.4 µg / mL). Imiti irimo batefenterol iri mubigeragezo byo kuvura indwara zidakira zifata ibihaha (COPD).

Intego: β2-adrenoeptor