BAY-1895344

Izina ryimiti:

(R) -3-methyl-4- (4- (1-methyl-1H-pyrazol-5-yl) -8-

Kode ya SMILES:

CN1N = CC = C1C2 = CC (N3 [C @ H] (C) COCC3) = NC4 = C (C5 = CC = NN5) N = CC = C24. [H] Cl

InChi Code:

InChI = 1S / C20H21N7O.ClH / c1-13-12-28-10-9-27 (13) 18-11-15 (17-5-8-23-26 (17) 2) 14-3-6- 21-20 (19 (14) 24-18) 16-4-7-22-25-16; / h3-8,11,13H, 9-10,12H2,1-2H3, (H, 22,25) ; 1H / t13 -; / m1./s1

InChi Urufunguzo:

KWQNBYGUBHMRPY-BTQNPOSSSA-N

Ijambo ryibanze:

1876467-74-1 ； CAS: 1876467-74-1 ； CAS ： 1876467-74-1 ； BAY-1895344, BAY1895344, BAY 1895344

Gukemura:Gukemura muri DMSO

Ububiko:0 - 4 ° C mugihe gito (iminsi kugeza ibyumweru), cyangwa -20 ° C mugihe kirekire (amezi).

Ibisobanuro:

BAY-1895344 ni ATR yatoranijwe (ataxia-telangiectasia na poroteyine ifitanye isano na Rad3) ibuza ikwirakwizwa ryinshi ryimirongo yibibyimba byabantu (median IC50 = 78 nM). BAY-1895344 yateguwe mu kuvura abarwayi bafite ibibyimba bikomeye na lymphoma, kandi iri mu cyiciro cya mbere cy’amavuriro y’umutekano no kwihanganira abarwayi ba kanseri.

Intego: ATR