| CAT # | Izina ryibicuruzwa | Ibisobanuro |
| CPD100573 | PF-05175157 | PF-07 ACC inihibitori ibuza de novo lipogenezi kandi ikongera β-okiside ya acide ya fatty acide ifite ubushobozi bwo kuvura diyabete yo mu bwoko bwa 2, steatose hepatike, na kanseri. |
| CPD100572 | ND-646 | ND-646 ni-allosteric inhibitor yimisemburo ya ACC ACC1 na ACC2 irinda ACC subunit dimerisation-guhagarika synthesis ya fatty acide muri vitro no muri vivo. Ubuvuzi bwa karande ND-646 bwo kuvura xenograft hamwe na genetike yimbeba ya NSCLC yabujije ikura ryikibyimba. Iyo ikozwe nkumukozi umwe cyangwa ifatanije nubuvuzi busanzwe bwa carboplatine, ND-646 yahagaritse cyane ikibyimba cyibihaha muri Kras; Trp53 - / - (izwi kandi nka KRAS p53) na Kras; Stk11 - / - ( bizwi kandi nka KRAS Lkb1) imiterere yimbeba ya NSCLC. ND-646 yariyongereye imbaraga mugihe ihujwe na karboplatine, igice rusange cyimiti ya chimiotherapeutique ikoreshwa mu kuvura abantu NSCLC. |
| CPD100571 | CP-640186 | CP-640186 ninzitizi ikomeye ya ACCs y’inyamabere kandi irashobora kugabanya uburemere bwumubiri no kunoza insuline mu nyamaswa zipimishije. CP-640186 iherutse kwerekana ko ari inzitizi ikomeye ya isoforms y’inyamabere ACCs zifite agaciro ka IC50 zifite agaciro ka 55 nM. Ubu ni bwo bwonyine buvugwa cyane bubuza inyamaswa z’inyamabere. Mu mico y'utugingo kimwe no mubyitegererezo by'inyamaswa, CP-640186 irashobora kugabanya urugero rwa tissue malonyl-CoA, ikabuza aside irike biosynthesis, kandi igatera aside irike. Icy'ingenzi cyane, CP-640186 irashobora kugabanya ibinure byumubiri nuburemere bwumubiri, kandi ikanongerera insuline ibyiyumvo, kwemeza ACC nkibitego byibasira imiti igabanya ubukana hamwe na antidiabete. |
| CPD1592 | ND-630 | ND-630 ni inibitori ya acetyl-CoA carboxylase (ACC); ibuza abantu ACC1 na ACC2 hamwe na IC50 agaciro ka 2.1 na 6.1 nM. |
