Nazartinib; EGF816; NVS-816

Izina ryimiti:

(R, E) -N- (7-chloro-1- (1- (4- (dimethylamino)) -2 2-methylisonicotinamide

Kode ya SMILES:

O = C (NC1 = NC2 = CC = CC (Cl) = C2N1 [C @ H] 3CN (C (/ C = C / CN (C) C) = O) CCCC3) C4 = CC = NC (C) = C4

InChi Code:

InChI = 1S / C26H31ClN6O2 / c1-18-16-19 (12-13-28-18) 25 (35) 30-26-29-22-10-6-9-21 (27) 24 (22) 33 ( 26) 20-8-4-5-15 -32 (17-20) 23 (34) 11-7-14-31 (2) 3 / h6-7,9-13,16,20H, 4-5,8,14-15,17H2,1-3H3 , (H, 29,30,35) / b11-7 + / t20- / m1 / s1

InChi Urufunguzo:

IOMMMLWIABWRKL-WUTDNEBXSA-N

Ijambo ryibanze:

Nazartinib, EGF816, EGF-816, EGF 816, NVS-816, 1508250-71-2

Gukemura:Gukemura muri DMSO

Ububiko:0 - 4 ° C mugihe gito (iminsi kugeza ibyumweru), cyangwa -20 ° C mugihe kirekire (amezi)

Ibisobanuro:

Nazartinib, izwi kandi nka EGF816 na NVS-816, ni umunwa uraboneka, udasubirwaho, igisekuru cya gatatu, mutant-selidive epidermal growth factor reseptor (EGFR) inhibitor, hamwe nibikorwa bya antineoplastique. EGF816 ihuza kandi ikabuza ibikorwa byimiterere ya mutant ya EGFR, harimo na T790M EGFR ihinduka, bityo ikabuza ibimenyetso bya EGFR. Ibi birashobora gutera urupfu kandi bikabuza gukura kwikibyimba muri selile yibibyimba bya EGFR-bikabije. EGF816 irabuza cyane uburyo bwahinduwe bwa EGFR harimo T790M, ihinduka rya kabiri rya mutation yo kurwanya, kandi irashobora kugira inyungu zo kuvura ibibyimba hamwe na T790M yunganirwa mugihe ugereranije nizindi EGFR tyrosine kinase inhibitor.

Intego: EGFR