LX-2761

Izina ryimiti:

N- (1 - ((2- (Dimethylamino) ethyl) amino) -2-methyl-1-oxopropan-2-yl) -4- (4- (2-methyl-5 - ((2S, 3R, 4R, 5S, 6R) -3,4,5-trihydroxy-6- (methylthio) tetrahydro-2H-pyran-2-yl) benzyl) fenyl) -butanamide

Kode ya SMILES:

O = C (NC (C) (C) C (NCCN (C) C) = O) CCCC1 = CC = C (CC2 = CC ([C @ H] 3 [C @ H] (O) [C @@ H] (O) [C @ H] (O) [C @@ H] (SC) O3) = CC = C2C) C = C1

InChi Code:

InChI = 1S / C32H47N3O6S / c1-20-10-15-23 (29-27 (38) 26 (37) 28 (39) 30 (41-29) 42-6) 19-24 (20) 18-22- 13-11-21 (12-14-22) 8-7-9-25 (36) 34-32 (2,3) 31 (40) 33-16-17-35 (4) 5 / h10-15, 19,26-30,37-39H, 7-9,16-18H2,1-6H3, (H, 33,40) (H, 34,36) / t26-, 27-, 28 +, 29 +, 30 - / m1 / s1

InChi Urufunguzo:

BNPZTRDIESRGTC-IXYVTWBDSA-N

Ijambo ryibanze:

LX-2761, LX2761, LX 2761, 1610954-97-6

Gukemura:Gukemura muri DMSO

Ububiko:0 - 4 ° C mugihe gito (iminsi kugeza ibyumweru), cyangwa -20 ° C mugihe kirekire (amezi).

Ibisobanuro:

LX2761 ni inhibitor ya SGLT1 ikora cyane muri vitro kandi ikadindiza kwinjiza amara glucose muri vivo kugirango irusheho kurwanya glycemic. LX2761 ifite hSGLt1 2.2 nM; hSGLT2 2.7 nM na F% =<2. LX2761 ni molekile ikomeye cyane, ihamye ya chimique, kandi ihagaritswe kumurika byageze kubimenyetso muri OGTT kumupanga muke cyane. LX2761 yashizweho kugirango igume mu mara nyuma yo kubyara mu kanwa kugirango ibuze SGLT1 aho itagize ingaruka ku buryo bwa SGLT1 / 2 mu mpyiko.

Intego: SGLT1