MEK

CAT #	Izina ryibicuruzwa	Ibisobanuro
CPDB0157	BI-847325	BI-847325 ni indobanure ya MEK / Aurora kinase inhibitor ifite indangagaciro za IC50 zifite agaciro ka 3, 25, 15, 25, na 4 nM kuri X. laevis Aurora B, abantu Aurora A na Aurora C, hamwe na MEK1 na MEK2. Irashobora kubuza gukura no kubaho byombi kuvura-naive ndetse no kurwanya imiti ya selile ya melanoma, bikagabanya imvugo ya MEK na Mcl-1 mugihe byongera imvugo ya poroteyine Bim-apoptotique Bim. Kuri mg / kg 70, BI-847325 itera apoptose mu kuvura-naive kandi irwanya ibiyobyabwenge xenografted melanoma muri vivo.