| CAT # | Izina ryibicuruzwa | Ibisobanuro |
| CPD9470 | Obeticholike-Acide | Acide ya Obeticholike (INT747; 6-ECDCA) ni igitabo gishya gikomoka kuri aside ya cholike ikora nka agoniste FXR ikomeye kandi itoranya yerekana ibikorwa bya anticholeretique muri vivo yimbeba ya cholestasis. Irabuza imitsi itwara imitsi ingirabuzimafatizo no kwimuka kimwe no guteza imbere itandukaniro rya adipocyte kandi ikagenga imikorere ya selile muri vivo. |
| CPD100579 | fexaramine | Fexaramine ni agoniste ya reseptor ya farnesoid X (FXR), ikaba ari reseptor ya acide ikoreshwa na acide igenzura synthesis ya aside-aside, conjugation hamwe nogutwara, ndetse na metabolisme ya lipide binyuze mubikorwa byumwijima no mara. Fexaramine ifite inshuro 100 zifitanye isano na FXR kuruta ibinyabuzima bisanzwe kandi isobanura intego za genomic hamwe na site ihuza FXR. Iyo itanzwe mu kanwa ku mbeba, fexaramine yabyaye ibikorwa byatoranijwe binyuze muri reseptor ya FXR mu mara. |
| CPD100577 | Litokolike-aside | Levallorphan, izwi kandi nka levallorphan tartate (USAN), ni moderi ya opioid modulator yumuryango wa morphinan ikoreshwa nka opioid analgesic na opioid antagonist / antidote. Ikora nka antagonist ya μ-opioid reseptor (MOR) kandi nka agoniste wa κ-opioid reseptor (KOR), kandi nkigisubizo, ihagarika ingaruka zimikorere ikomeye hamwe nibikorwa binini byimbere nka morphine mugihe icyarimwe itanga analgesia . Nka agoniste wa KOR, levallorphan irashobora gutanga ibitekerezo bikabije mumitekerereze ihagije harimo salusitini, gutandukana, nizindi ngaruka zo mumitekerereze, dysphoriya, guhangayika, urujijo, kuzunguruka, gutandukana, gutesha agaciro, kumva inzoga, ninzozi zidasanzwe, zidasanzwe, cyangwa zibangamira inzozi. . (Inkomoko: https://en.wikipedia.org/wiki/Levallorphan). |
| CPD100575 | Turofexorate-Isopropyl | Turofexorate isopropyl, izwi kandi nka WAY-362450 na XL335, ni agonist ikomeye cyane, itoranya, kandi ikora mu kanwa ka reseptor ya farnesoid X (FXR) (EC (50) = 4 nM, Eff = 149%), yongerera umuriro umwijima. na fibrosis muburyo bwa murine bwa steatohepatitis idafite inzoga |
| CPD100574 | GW4064 | GW4064 receptor farnesoid X reseptor (FXR) 激动剂， CV1 细胞系中 EC50 为 65 nM 。浓度达到 1 μM 时，对其他核受体没有活性。 |
| CPD1549 | Tropifexor | Tropifexor nigitabo kandi gikomeye cyane agonist ya FXR hamwe na EC50 ya 0.2 nM. |
