Osimertinib Mesylate

Osimertinib Mesylate
  • Izina:AZD-9291 (Mesylate); Tagrisso; Osimertinib Mesylate
  • Cataloge No.:CPDB0137
  • CAS No.:1421373-66-1
  • Uburemere bwa molekile:595.72
  • Imiti yimiti:C29H37N7O5S
  • Kubushakashatsi bwa siyansi gusa, ntabwo kubarwayi.

    Ibicuruzwa birambuye

    Ibicuruzwa

    Ingano Kuboneka Igiciro (USD)
    500mg Mububiko 100
    1g Mububiko 180
    5g Mububiko 600
    Ingano nini Shaka Amagambo Shaka Amagambo

    Izina ryimiti:

    N- (2 - ((2- (dimethylamino) ethyl) (methyl) amino) -4-mikorerexy-5 - ((4- ) fenyl) acrylamide mesylate

    Kode ya SMILES:

    CN (CCN (C) C) C1 = CC (OC) = C (C = C1NC (C = C) = O) NC2 = NC = CC (C3 = CN (C) C4 = C3C = CC = C4) = N2 .OS (= O) (C) = O.

    InChi Code:

    InChI = 1S / C28H33N7O2.CH4O3S / c1-7-27 (36) 30-22-16-23 (26 (37-6) 17-25 (22) 34 (4) 15-14-33 (2) 3) 32-28-29-13-12-21 (31-28) 20-18-35 (5) 24-11-9-8-10-19 (20) 24; 1-5 (2,3) 4 / h7-13,16-18H, 1,14-15H2,2-6H3, (H, 30,36) (H, 29,31,32); 1H3, (H, 2,3,4)

    InChi Urufunguzo:

    FUKSNUHSJBTCFJ-UHFFFAOYSA-N

    Ijambo ryibanze:

    AZD-9291, AZD9291, AZD 9291, Tagrisso, Osimertinib Mesylate, 1421373-66-1

    Gukemura:Gukemura muri DMSO

    Ububiko:0 - 4 ° C mugihe gito (iminsi kugeza ibyumweru), cyangwa -20 ° C mugihe kirekire (amezi)

    Ibisobanuro:

    Osimertinib, izwi kandi ku izina rya mereletinib na AZD-9291, ni igisekuru cya gatatu cya EGFR inhibitor, yerekanye amasezerano mu bushakashatsi bwibanze kandi itanga ibyiringiro ku barwayi bafite kanseri y'ibihaha yateye imbere barwanya indwara ya EGFR ihari. AZD9291 ikora cyane muburyo bwa preclinical kandi irihanganirwa mubyitegererezo by'inyamaswa. Irabuza gukora no kurwanya ihindagurika rya EGFR mugihe irinze uburyo busanzwe bwa EGFR igaragara mu ngirabuzimafatizo zisanzwe z’uruhu n’inda, bityo bikagabanya ingaruka mbi zihura n’imiti iboneka ubu. Osimertinib yemejwe ku ya 2015 Ugushyingo.

    Intego: EGFR


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