Sodium ya CP-456773

Sodium ya CP-456773
  • Izina:Sodium ya CP-456773
  • Cataloge No.:CPDD1600
  • CAS No.:256373-96-3
  • Uburemere bwa molekile:426.4628
  • Imiti yimiti:C20H23N2NaO5S
  • Kubushakashatsi bwa siyansi gusa, ntabwo kubarwayi.

    Ibicuruzwa birambuye

    Ibicuruzwa

    Ingano Kuboneka Igiciro (USD)
    100mg Mububiko 500
    500mg Mububiko 800
    1g Mububiko 1200
    Ingano nini Shaka Amagambo Shaka Amagambo

    Izina ryimiti:

    sodium ((1,2,3,5,6,7-hexahydro-s-indacen-4-yl) karbamoyl) ((4- (2-hydroxypropan-2-yl) furan-2-yl) sulfonyl) amide

    Kode ya SMILES:

    O = S (C1 = CC (C (C) (O) C) = CO1) ([N-] C (NC2 = C3CCCC3 = CC4 = C2CCC4) = O) = O. [Na +]

    InChi Code:

    InChI = 1S / C20H24N2O5S.Na / c1-20 (2,24) 14-10-17 (27-11-14) 28 (25,26) 22-19 (23) 21-18-15-7-3- 5-12 (15) 9-13-6-4-8-16 (13) 18; / h9-11,24H, 3-8H2,1-2H3, (H2,21,22,23); / q; + 1 / p-1

    InChi Urufunguzo:

    LFQQNXFKPNZRFT-UHFFFAOYSA-M

    Ijambo ryibanze:

    MCC950, MCC 950, MCC-950, CP-45677, CP45677, CP 45677, CRID-3, CRID3, CRID 3, CP-456773 umunyu wa sodium, Cytokine irekura imiti ibuza 3, 256373-96-3

    Gukemura:Gukemura muri DMSO

    Ububiko:0 - 4 ° C mugihe gito (iminsi kugeza ibyumweru), cyangwa -20 ° C mugihe kirekire (amezi).

    Ibisobanuro:

    CP-456773, izwi kandi nka MCC950 na CRID3, ni inzitizi ikomeye kandi ihitamo cytokine irekura hamwe na NLRP3 inhibmasitori yo kuvura indwara zanduza. CP-456773 ibuza interleukin 1β (IL-1β) gusohora no gutunganya caspase 1. MCC950 yahagaritse ibikorwa bya Canonical na noncanonical NLRP3 yibitekerezo bya nanomolar. MCC950 yabujije cyane ibikorwa bya NLRP3 ariko ntabwo AIM2, NLRC4 cyangwa NLRP1 inflammasomes. MCC950 yagabanije umusaruro wa interleukin-1β (IL-1β) muri vivo kandi byerekana ubukana bwa autoimmune encephalomyelitis (EAE), urugero rwindwara ya sclerose nyinshi. MCC950 ni uburyo bushobora kuvura syndromes zifitanye isano na NLRP3, zirimo indwara ziterwa na autoinflammatory na autoimmune, hamwe nigikoresho cyo gukomeza kwiga ubushakashatsi bwa NLRP3 mu buzima bwabantu nindwara.

    Intego: NLRP3


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