GSK2256098

Izina ryimiti:

2 - (((5-chloro-2 - (((1

Kode ya SMILES:

CC1 = NN (C (= C1) NC2 = NC = C (C (= C2) NC3 = CC = CC = C3C (= O) NOC) Cl) C (C) C

InChi Code:

InChI = 1S / C20H23ClN6O2 / c1-12 (2) 27-19 (9-13 (3) 25-27) 24-18-10-17 (15 (21) 11-22-18) 23-16-8- 6-5-7-14 (16) 20 (28) 26-29-4 / h5-12H, 1-4H3, (H, 26,28) (H2,22,23,24)

InChi Urufunguzo:

BVAHPPKGOOJSPU-UHFFFAOYSA-N

Ijambo ryibanze:

GSK2256098, GSK-2256098, GSK 2256098, GTPL7939, GTPL 7939, GTPL-7939, 1224887-10-8

Gukemura:Gukemura muri DMSO

Ububiko:0 - 4 ° C mugihe gito (iminsi kugeza ibyumweru), cyangwa -20 ° C mugihe kirekire (amezi).

Ibisobanuro:

GSK2256098, izwi kandi nka GTPL7939, ni inhibitor ya kinase-1 (FAK) inhibitor hamwe nibikorwa bishobora kurwanya antangiyogenike na antineoplastique. FAK inhibitor GSK2256098 irabuza FAK, ishobora gukumira ibikorwa bya enterin-medrated yoguhuza inzira nyinshi zohereza ibimenyetso byamanuka, harimo ERK, JNK / MAPK na PI3K / Akt, bityo bikabuza kwimuka kwimitsi yibibyimba, gukwirakwizwa no kubaho, hamwe na angiogenez. Tyrosine kinase FAK mubisanzwe ikorwa muguhuza integin muri matrice idasanzwe (ECM) ariko irashobora gutegekwa kandi igakora muburyo butandukanye bwimikorere yibibyimba.

Intego: FAK