| CPDB0099 | Quizartinib; AC-010220; AC-220 | Quizartinib ni inhibitori ya FMS ifitanye isano na tyrosine kinase 3 (FLT3; Kd = 1,6 nM) kandi irerekana guhitamo kwinshi kuri FLT3 mugihe igeragezwa hamwe na 227 yinyongera ya kinase. Irabuza ikwirakwizwa ry'umurongo w'ingirabuzimafatizo ya muntu MV4-11, ibamo ihinduka ry’imiterere ya FLT3-ITD, ifite IC50 ifite agaciro ka 0.56 nM.1 Kuri 1 mg / kg / ku munsi, quizartinib yerekanwe ko ishobora kubaho mu mbeba. icyitegererezo cya FLT3-ITD acute myeloid leukemia no kurandura ibibyimba muburyo bwa FLT3 bushingiye ku mbeba xenograft yerekana 10 mg / kg. |
