MSC2530818
Tsatanetsatane wa Zamalonda
Zolemba Zamalonda
| Paketi Kukula | Kupezeka | Mtengo (USD) |
| 100 mg | Zilipo | 400 |
| Makulidwe Enanso | Pezani Mawu | Pezani Mawu |
Dzina la Chemical:
[(2S)-2-(4-Chlorophenyl)pyrrolidin-1-yl]-(3-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl)methanone
SMILES Kodi:
O=C(N1[C@H](C2=CC=C(Cl)C=C2)CCC1)C3=CN=C(NN=C4C)C4=C3
InChi kodi:
InChI=1S/C18H17ClN4O/c1-11-15-9-13(10-20-17(15)22-21-11)18(24)23-8-2-3-16(23)12-4- 6-14(19)7-5-12/h4-7,9-10,16H,2-3,8H2,1H3,(H,20,21,22)/t16-/m0/s1
InChi Key:
ODRITQGYYWHQGM-INIZCTEOSA-N
Mawu ofunika:
MSC2530818, MSC-2530818, MSC 2530818, 1883423-59-3
Kusungunuka:Zosungunuka mu DMSO
Posungira:0 - 4 ° C kwa nthawi yochepa (masiku mpaka masabata), kapena -20 ° C kwa nthawi yaitali (miyezi).
Kufotokozera:
MSC2530818 ndi Mphamvu Yamphamvu, Yosankha, ndi Olly Bioavailable CDK8 Inhibitor yokhala ndi CDK8 IC50 = 2.6 nM; Kuneneratu kwa PK yaumunthu: Cl ~ 0.14 L/H/Kg; t1/2 ~ 2.4h; F> 75%. MSC2530818 imawonetsa kusankhidwa bwino kwa kinase, potency ya biochemical ndi ma cell, kukhazikika kwa microsomal, ndipo imapezeka pakamwa. MSC2530818 ikuwonetsa potency yoyenera ndikusankha kuti mupite patsogolo mu maphunziro achitetezo a vivo komanso maphunziro achitetezo.
Cholinga: CDK
