PQR530
Tsatanetsatane wa Zamalonda
Zolemba Zamalonda
| Paketi Kukula | Kupezeka | Mtengo (USD) |
| 100 mg | Zilipo | 500 |
| 500 mg | Zilipo | 800 |
| 1g | Zilipo | 1200 |
| Makulidwe Enanso | Pezani Mawu | Pezani Mawu |
Dzina la Chemical:
(S) -4-(difluoromethyl)-5-(4-(3-methylmorpholino)-6-morpholino-1,3,5-triazin-2-yl)pyridin-2-amine
SMILES Kodi:
NC1=NC=C(C2=NC(N3[C@H](C)COCC3)=NC(N4CCOCC4)=N2)C(C(F)F)=C1
InChi kodi:
InChI=1S/C18H23F2N7O2/c1-11-10-29-7-4-27(11)18-24-16(13-9-22-14(21)8-12(13)15(1 9)20)23-17(25-18)26-2-5-28-6-3-26/h8-9,11,15H,2-7,10H2,1H3,(H2,21,22)/ t11-/m0/s1
InChi Key:
SYKBZXMKAPICSO-NSHDSACASA-N
Mawu ofunika:
PQR530, PQR-530, PQR 530, 1927857-61-1
Kusungunuka:Zosungunuka mu DMSO
Posungira:0 - 4 ° C kwa nthawi yochepa (masiku mpaka masabata), kapena -20 ° C kwa nthawi yaitali (miyezi).
Kufotokozera:
PQR530 ndi yamphamvu kwambiri yapawiri pan-PI3K/mTORC1/2 inhibitor. PQR530 inhibited protein kinase B (PKB, pSer473) ndi ribosomal protein S6 (pS6, pSer235/236) phosphorylation yokhala ndi IC50 milingo ya 0.07 µM. PQR530 idawonetsa kusankhidwa kwabwino kwambiri pamagawo ambiri a kinase, komanso kusankha bwino kwambiri motsutsana ndi ma enzymes osagwirizana ndi ma ion njira. Kuphatikiza apo, PQR530 idawonetsa potency mu gulu la 44 cell cell lines (NTRC Oncolines TM) kuti ateteze kukula kwa maselo a khansa (kutanthauza mtengo wa GI50 wa 426 nM). Kugwiritsa ntchito pakamwa kwa PQR530 kwa mbewa kunapangitsa kuti pakhale PK yofanana ndi mlingo ndikuwonetsa bwino pakamwa bioavailability ndi kulowa muubongo wabwino kwambiri.
Cholinga: PI3K/mTOR
