BI-847325
Tsatanetsatane wa Zamalonda
Zolemba Zamalonda
| Paketi Kukula | Kupezeka | Mtengo (USD) |
| 100 mg | Zilipo | 400 |
| 500 mg | Zilipo | 950 |
| 1g | Zilipo | 1400 |
| Makulidwe Enanso | Pezani Mawu | Pezani Mawu |
Dzina la Chemical:
(Z)-3-(3-(((4-((dimethylamino)methyl)phenyl)amino)(phenyl)methylene)-2-oxoindolin-6-yl)-N-ethylpropiolamide
SMILES Kodi:
O=C(NCC)C#CC1=CC(NC/2=O)=C(C=C1)C2=C(NC3=CC=C(CN(C)C)C=C3)/C4=CC= CC=C4
InChi kodi:
InChI=1S/C29H28N4O2/c1-4-30-26(34)17-13-20-12-16-24-25(18-20)32-29(35)27(24)28(22-8- 6-5-7-9-2 2)31-23-14-10-21(11-15-23)19-33(2)3/h5-12,14-16,18,31H,4,19H2,1-3H3,(H,30 ,34)(H,32,35)/b28-27-
InChi Key:
FLBNLJLONKAPLR-DQSJHHFOSA-N
Mawu ofunika:
BI-847325, BI847325, BI 847325, 1207293-36-4
Kusungunuka:Zosungunuka mu DMSO
Posungira:0 - 4 ° C kwa nthawi yochepa (masiku mpaka masabata), kapena -20 ° C kwa nthawi yaitali (miyezi)
Kufotokozera:
BI-847325 ndi yosankha yapawiri ya MEK/Aurora kinase inhibitor yokhala ndi IC50 milingo ya 3, 25, 15, 25, ndi 4 nM ya X. laevis Aurora B, Aurora A yamunthu ndi Aurora C, ndi MEK1 yamunthu ndi MEK2 motsatana. Itha kulepheretsa kukula ndi kupulumuka kwa mizere ya melanoma yopanda chithandizo komanso yosamva mankhwala, kumachepetsa mawu a MEK ndi Mcl-1 ndikuwonjezera kufotokoza kwa pro-apoptotic protein Bim. Pa 70 mg/kg, BI-847325 imapangitsa apoptosis mu mankhwala osachiritsika komanso osamva mankhwala a xenografted melanoma mu vivo.
Cholinga: MEK/Aurora
