Nazartinib; EGF816; Mtengo wa NVS-816
Tsatanetsatane wa Zamalonda
Zolemba Zamalonda
| Paketi Kukula | Kupezeka | Mtengo (USD) |
| 25 mg pa | Zilipo | 290 |
| 50 mg pa | Zilipo | 450 |
| 100 mg | Zilipo | 630 |
| 1g | Zilipo | 1600 |
| Makulidwe Enanso | Pezani Mawu | Pezani Mawu |
Dzina la Chemical:
(R,E)-N-(7-chloro-1-(1-(4-(dimethylamino)koma-2-enoyl)azepan-3-yl)-1H-benzo[d]imidazol-2-yl)- 2-methylisonicotinamide
SMILES Kodi:
O=C(NC1=NC2=CC=CC(Cl)=C2N1[C@H]3CN(C(/C=C/CN(C)C)=O)CCCC3)C4=CC=NC(C)= C4
InChi kodi:
InChI=1S/C26H31ClN6O2/c1-18-16-19(12-13-28-18)25(35)30-26-29-22-10-6-9-21(27)24(22)33( 26)20-8-4-5-15-32(17-20)23(34)11-7-14-31(2)3/h6-7,9-13,16,20H,4-5, 8,14-15,17H2,1-3H3,(H,29,30,35)/b11-7+/t20-/m1/s1
InChi Key:
IOMMMLWIABWRKL-WUTDNEBXSA-N
Mawu ofunika:
Nazartinib ,EGF816, EGF-816, EGF 816, NVS-816, 1508250-71-2
Kusungunuka:Zosungunuka mu DMSO
Posungira:0 - 4 ° C kwa nthawi yochepa (masiku mpaka masabata), kapena -20 ° C kwa nthawi yaitali (miyezi)
Kufotokozera:
Nazartinib, yomwe imadziwikanso kuti EGF816 ndi NVS-816, imapezeka pakamwa, yosasinthika, ya m'badwo wachitatu, mutant-selective epidermal growth factor receptor (EGFR) inhibitor, yomwe ingathe kuchitapo kanthu. EGF816 imamangiriza ndikulepheretsa ntchito zamitundu yosinthika ya EGFR, kuphatikiza kusintha kwa T790M EGFR, potero kulepheretsa kusaina kwa EGFR. Izi zitha kuyambitsa kufa kwa cell ndikuletsa kukula kwa chotupa mu EGFR-overexpressing chotupa maselo. EGF816 makamaka imalepheretsa mitundu yosinthika ya EGFR kuphatikiza T790M, kusinthika komwe kunapezedwa kachiwiri, ndipo ikhoza kukhala ndi chithandizo chamankhwala m'matumbo omwe ali ndi T790M-mediated resistance poyerekeza ndi ena EGFR tyrosine kinase inhibitors.
Cholinga: EGFR
