Chithunzi cha GLPG0187
Tsatanetsatane wa Zamalonda
Zolemba Zamalonda
| Paketi Kukula | Kupezeka | Mtengo (USD) |
| 100 mg | Zilipo | 650 |
| 250 mg | Zilipo | 960 |
| 500 mg | Zilipo | 1500 |
| Makulidwe Enanso | Pezani Mawu | Pezani Mawu |
Dzina la Chemical:
(S) -3-((2,5-dimethyl-6-(4-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)piperidin-1-yl)pyrimidin-4- yl) amino) -2-((4-methoxyphenyl)sulfonamido)propanoic acid
SMILES Kodi:
O=C(O)[C@H](CNC1=NC(C)=NC(N2CCC(C3=NC4=C(CCCN4)C=C3)CC2)=C1C)NS(=O)(C5=CC= C(OC)C=C5)=O
InChi kodi:
InChI=1S/C29H37N7O5S/c1-18-26(31-17-25(29(37)38)35-42(39,40)23-9-7-22(41-3)8-10-23) 32-19(2)33-28(18)36-15-12-20(13-16-36)24-11-6-21-5-4-14-30-27(21)34-24/ h6-11,20,25,35H,4-5,12-17H2,1-3H3,(H,30,34)(H,37,38)(H,31,32,33)/t25-/m0 /s1
InChi Key:
CXHCNOMGODVIKB-VWLOTQADSA-N
Mawu ofunika:
GLPG0187, GLPG-0187, GLPG 0187, 1320346-97-1
Kusungunuka:Zosungunuka mu DMSO
Posungira:0 - 4 ° C kwa nthawi yochepa (masiku mpaka masabata), kapena -20 ° C kwa nthawi yaitali (miyezi).
Kufotokozera:
Pakuyesa kolimba, GLPG0187 ikuwonetsa kusankhidwa kwa ma RGD integrin receptors angapo okhala ndi IC50s a 1.3, 3.7, 2.0, 1.4, 1.2, 7.7 nM kwa αvβ1, αvβ3, αvβ5, αvβ6, αvβ8, ndi αvβ8, ndi. GLPG0187 ndi inhibitor yamphamvu ya osteoclastic bone resorption ndi angiogenesis. Kuchiza ndi GLPG0187 kumadalira mlingo kumawonjezera chiŵerengero cha E-cadherin/vimentin, kupangitsa maselo kukhala epithelial, sessile phenotype. GLPG0187 mlingo-kudalira kumachepetsa kukula kwa aldehyde dehydrogenase kuchuluka kwa maselo a khansa ya prostate [1]. Chithandizo cha GLPG0187 chimapangitsa kuti ma cell azungulire komanso kuphatikizika. GLPG0187 ikuwonetsa kuchepa kwakukulu kodalira mlingo pakusuntha kwa maselo a chotupa. GLPG0187 nthawi zonse imachepetsa kuchulukana kwa maselo [2].
Cholinga: αvβ1
