Chithunzi cha RGX-104
Tsatanetsatane wa Zamalonda
Zolemba Zamalonda
| Paketi Kukula | Kupezeka | Mtengo (USD) |
| 100 mg | Zilipo | 500 |
| 500 mg | Zilipo | 800 |
| 1g | Zilipo | 1200 |
| Makulidwe Enanso | Pezani Mawu | Pezani Mawu |
Dzina la Chemical:
(R) -2- [3- [3- [[2-Chloro-3-(trifluoromethyl)benzyl](2,2-diphenylethyl)amino]-3-methylpropoxy]phenyl]acetic acid hydrochloride
SMILES Kodi:
O=C(O)CC1=CC=CC(OCC[C@H](N(CC2=CC=CC(C(F)(F)F)=C2Cl)CC(C3=CC=CC=C3)C4 =CC=CC=C4)C)=C1.[H]Cl
InChi kodi:
InChI=1S/C34H33ClF3NO3.ClH/c1-24(18-19-42-29-16-8-10-25(20-29)21-32(40)41)39(22-28-15-9- 17-31(33(28)35)34(36,37)38)23-30(26-11-4-2-5-12-26)27-13-6-3-7-14-27; /h2-17,20,24,30H,18-19,21-23H2,1H3,(H,40,41);1H/t24-;/m1./s1
InChi Key:
LCMIYQOJZLRHTO-GJFSDDNBSA-N
Mawu ofunika:
RGX-104 HCl, RGX-104, RGX104, RGX 104, 610318-03-1
Kusungunuka:Zosungunuka mu DMSO
Posungira:0 - 4 ° C kwa nthawi yochepa (masiku mpaka masabata), kapena -20 ° C kwa nthawi yaitali (miyezi).
Kufotokozera:
RGX-104 ndi chiwindi cha X cholandirira beta agonist chokhala ndi mphamvu zoteteza thupi komanso anti-antineoplastic. Poyang'anira pakamwa, RGX-104 imayang'ana ndikumangiriza ku LXRbeta, potero yambitsa chizindikiro cha LXRbeta-mediated, zomwe zimatsogolera ku kulembedwa kwa majini ena opondereza chotupa ndi kutsika kwa majini ena olimbikitsa chotupa. Izi makamaka zimathandizira mawu a apolipoprotein E (ApoE), mapuloteni opondereza chotupa, m'maselo otupa ndi ma cell ena oteteza thupi. Izi zimayendetsa chitetezo cham'mimba, zomwe zimapangitsa kuchepa kwa ma immunosuppressive myeloid-derived suppressor cell (MDSCs), ma cell chotupa ndi ma endothelial cell mu chotupa microenvironment. Izi zimachepetsa chitetezo chamthupi, zimawonjezera chitetezo chamthupi cha anti-chotupa ndikuletsa kuchuluka kwa maselo otupa.
Cholinga: LXRbeta
