Vactosertib
Tsatanetsatane wa Zamalonda
Zolemba Zamalonda
| Paketi Kukula | Kupezeka | Mtengo (USD) |
| 500 mg | Zilipo | 800 |
| 1g | Zilipo | 1300 |
| 5g | Zilipo | 3800 |
| Makulidwe Enanso | Pezani Mawu | Pezani Mawu |
Dzina la Chemical:
N-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methyl )-2-fluoroaniline
SMILES Kodi:
FC1=CC=CC=C1NCC2=NC(C3=CN4C(C=C3)=NC=N4)=C(C5=NC(C)=CC=C5)N2
InChi kodi:
InChI=1S/C22H18FN7/c1-14-5-4-8-18(27-14)22-21(15-9-10-20-25-13-26-30(20)12-15)28- 19(29-22)11-24-17-7-3-2-6-16(17)23/h2-10,12-13,24H,11H2,1H3,(H,28,29)
InChi Key:
FJCDSQATIJKQKA-UHFFFAOYSA-N
Mawu ofunika:
Vactosertib, EW-7197, EW7197, EW 7197, 1352608-82-2
Kusungunuka:Zosungunuka mu DMSO
Posungira:0 - 4 ° C kwa nthawi yochepa (masiku mpaka masabata), kapena -20 ° C kwa nthawi yaitali (miyezi)
Kufotokozera:
Vactosertib, yomwe imadziwikanso kuti EW-7197 ndi inhibitor yamphamvu ya ALK5. EW-7197 idawonetsa ntchito yamphamvu mu vivo anti-metastatic, kuwonetsa kuthekera kwake kogwiritsidwa ntchito ngati mankhwala oletsa khansa. EW-7197 imalepheretsa chizindikiro cha TGF-β/Smad. EW-7197 imachotsa TGF-β1-induced tumor cell migration ndi kuwukira. EW-7197 imaletsa metastasis ya khansa ya m'mawere ku lung.EW-7197 imatalikitsa moyo wa mbewa za BALB/c 4T1 kudzera kuletsa kwa EMT. EW-7197 imalepheretsa metastasis ndikuwonjezera ntchito ya cytotoxic T lymphocytes (CTLs) mu 4T1 orthotopic mbewa zomezanitsidwa.
Cholinga: ALK
