Mtengo wa ND-630
Tsatanetsatane wa Zamalonda
Zolemba Zamalonda
| Paketi Kukula | Kupezeka | Mtengo (USD) |
| 10 mg pa | Zilipo | 300 |
| 50 mg pa | Zilipo | 500 |
| 100 mg | Zilipo | 800 |
| Makulidwe Enanso | Pezani Mawu | Pezani Mawu |
Dzina la Chemical:
(R) -2-(1-(2-(2-methoxyphenyl)-2-((tetrahydro-2H-pyran-4-yl)oxy)ethyl)-5-methyl-6-(oxazol-2-yl) -2,4-dioxo-1,2-dihydrothieno[2,3-d]pyrimidin-3(4H)-yl) -2-methylpropanamide
SMILES Kodi:
O=C(N)C(C)(C)N(C(N(C[C@@H](C1=CC=CC=C1OC)OC2CCOCC2)C3=C4C(C)=C(C5=NC= CO5)S3)=O)C4=O
InChi kodi:
InChI=1S/C28H31N3O8S/c1-16-21-24(32)31(28(2,3)26(33)34)27(35)30(25(21)40-22(16)23-29- 11-14-38-23)15-20(3 9-17-9-12-37-13-10-17)18-7-5-6-8-19(18)36-4/h5-8,11,14,17,20H,9-10, 12-13,15H2,1-4H3,(H,33,34)/t20-/m0/s1
InChi Key:
ZZWWXIBKLBMSCS-FQEVSTJZSA-N
Mawu ofunika:
ND-630, ND630, ND 630, GS-0976, GS0976, GS 0976, NDI-010976, NDI010976, NDI 010976, Firsocostat, 1434635-54-7
Kusungunuka:Zosungunuka mu DMSO
Posungira:0 - 4 ° C kwa nthawi yochepa (masiku mpaka masabata), kapena -20 ° C kwa nthawi yaitali (miyezi).
Kufotokozera:
ND-630 imalepheretsa hACC1 (IC50=2.1±0.2 nM) ndi hACC2 (IC50=6.1±0.8 nM). Kuletsa ndikosinthika komanso kwapadera kwambiri kwa ACC. ND-630 imalepheretsa ntchito ya ACC polumikizana mkati mwa phosphopeptide-acceptor ndi dimerization site ya enzyme kuteteza dimerization. ND-630 imalepheretsa kaphatikizidwe ka mafuta acid ndi EC50 ya 66 nM m'maselo a HepG2 popanda kusintha kuchuluka kwa cell, kuchuluka kwa mapuloteni a cell, ndikuphatikiza acetate mu cholesterol[1].
Zolinga: ACC
