Bardoxolone methyl

Dzina la Chemical:

(4aS,6aR,6bS,8aR,12aS,14aR,14bS)-methyl 11-cyano-2,2,6a,6b,9,9,12a-heptamethyl-10,14-dioxo-1,2,3,4 ,4a,5,6,6a,6b,7,8,8a,9,10,12a,14,14a,14b-octadecahydropicene-4a-carboxylate

SMILES Kodi:

O=C([C@]1(CC[C@@]2(C)[C@]3(C)CCC4C(C)(C)C(C(C#N)=C[C@]4 (C)C3=C5)=O)CCC(C)(C)C[C@]1([H])[C@@]2([H])C5=O)OC

InChi kodi:

InChI=1S/C32H43NO4/c1-27(2)11-13-32(26(36)37-8)14-12-31(7)24(20(32)17-27)21(34)15- 23-29(5)16-19(18-33)25(35)28(3,4)22(29)9-10-30(23,31)6/h15-16,20,22,24H, 9-14,17H2,1-8H3/t20-,22?,24+,29+,30-,31-,32+/m1/s1

InChi Key:

WPTTVJLTNAWYAO-OROHISIGSA-N

Mawu ofunika:

Bardoxolone methyl, RTA-402, RTA 402, RTA402, NSC-713200, TP-155C, Methyl-CDDO, MethylCDDO, Methyl CDDO, CDDO methyl ester, 218600-53-4

Kusungunuka:Zosungunuka mu DMSO

Posungira:0 - 4 ° C kwa nthawi yochepa (masiku mpaka masabata), kapena -20 ° C kwa nthawi yaitali (miyezi)

Kufotokozera:

The synthetic oleanane triterpenoid CDDO (Item No. 81035) ndi Nrf2 activator yomwe imalepheretsa kufalikira ndi kuchititsa kusiyanitsa ndi apoptosis m'maselo osiyanasiyana a khansa. C-28 methyl ester ya CDDO (CDDO methyl ester) imatchinga kaphatikizidwe ka cell ka inducible nitric oxide synthase (iNOS) ndi inducible COX-2 mu INF-γ-activated mouse macrophages ndi IC50 mtengo wa 0.11 nM. Zimayambitsa apoptosis, zimapangitsa kusiyana, ndipo zimalepheretsa kuyankhidwa kwa kutupa m'maselo osiyanasiyana a chotupa mwa kuletsa chizindikiro cha IκBα kinase/NF-κB. CDDO methyl ester ili ndi zochita zamphamvu za antidiabetic, kuchepetsa proinflammatory cytokine expression in high fat diet-feed type 2 diabetic mbewa komanso Leprdb/db mbewa ndikuyambitsa AMP-activated protein kinase ndi LKB1 activation mu minofu ndi chiwindi.

Cholinga: NF-kB