Batefenterol
Tsatanetsatane wa Zamalonda
Zogulitsa Tags
| Paketi Kukula | Kupezeka | Mtengo (USD) |
| 50 mg pa | Zilipo | 200 |
| 250 mg | Zilipo | 600 |
| 500 mg | Zilipo | 900 |
| 1g | Zilipo | 1400 |
| Makulidwe Enanso | Pezani Mawu | Pezani Mawu |
Dzina la Chemical:
"(R) -1-(3-((2-chloro-4-(((2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl)amino) methyl)-5-methoxyphenyl)amino)-3-oxopropyl)piperidin-4-yl [1,1'-biphenyl]-2-ylcarbamate Batefenterol Succinate"
SMILES Kodi:
O=C(OC1CCN(CCC(NC2=CC(OC)=C(CNC[C@H](O)C3=CC=C(O)C4=C3C=CC(N4)=O)C=C2Cl)= O)CC1)NC5=CC=CC=C5C6=CC=CC=C6
InChi kodi:
InChI=1S/C40H42ClN5O7/c1-52-36-22-33(31(41)21-26(36)23-42-24-35(48)2 9-11-13-34(47)39-30(29)12-14-37(49)45-39)43-38(50)17-20-46-18-15-27(1 6-19-46)53-40(51)44-32-10-6-5-9-28(32)25-7-3-2-4-8-25/h2-14,21-22, 27, 35,42,47-48H,15-20,23-24H2,1H3,(H,43,50)(H,44,51)(H,45,49)/t35-/m0/s1
InChi Key:
URWYQGVSPQJGGB-DHUJRADRSA-N
Mawu ofunika:
Batefenterol, TD-5959, GSK961081, 743461-65-6, GSK-961081, GSK 961081, TD5959, TD 5959, 743461-65-6
Kusungunuka:Zosungunuka mu DMSO
Posungira:0 - 4 ° C kwa nthawi yochepa (masiku mpaka masabata), kapena -20 ° C kwa nthawi yaitali (miyezi)
Kufotokozera:
Batefenterol ndi muscarinic antagonist ndi β2-adrenergic receptor (β2-AR) agonist (Kis = 1.4, 1.3, ndi 3.7 nM, kwa hM2, hM3, ndi hβ2-AR, motsatira muyeso yomangirira ya radioligand). Batefenterol imasonyeza ntchito yamphamvu ya hβ2-AR agonist (EC50 = 0.29 nM) yokhala ndi 440- ndi 320-fold functional selectivity pa hβ1- ndi hβ3-ARs, motero.1 Batefenterol imapangitsa kuti minofu ikhale yosalala (EC50 = 11 nM) m'mphepete mwa nyanja ya tracheal minofu ndikuletsa kuyankha kwa bronchoconstrictor mu a kuyesa kwa bronchoprotection ya nkhumba (ED50 = 6.4 µg/mL). Mapangidwe okhala ndi batefenterol ali m'mayesero azachipatala kuti athe kuchiza matenda osachiritsika a m'mapapo (COPD).
Cholinga: β2-adrenoceptor
