GSK2256098
Tsatanetsatane wa Zamalonda
Zolemba Zamalonda
| Paketi Kukula | Kupezeka | Mtengo (USD) |
| 100 mg | Zilipo | 450 |
| 1g | Zilipo | 2000 |
| Makulidwe Enanso | Pezani Mawu | Pezani Mawu |
Dzina la Chemical:
2-((5-chloro-2-((1-isopropyl-3-methyl-1H-pyrazol-5-yl)amino)pyridin-4-yl)amino)-N-methoxybenzamide
SMILES Kodi:
CC1=NN(C(=C1)NC2=NC=C(C(=C2)NC3=CC=CC=C3C(=O)NOC)Cl)C(C)C
InChi kodi:
InChI=1S/C20H23ClN6O2/c1-12(2)27-19(9-13(3)25-27)24-18-10-17(15(21)11-22 -18)23-16-8-6-5-7-14(16)20(28)26-29-4/h5-12H,1-4H3,(H,26,28)(H2,22,23) , 24)
InChi Key:
BVAHPPKGOOJSPU-UHFFFAOYSA-N
Mawu ofunika:
GSK2256098, GSK-2256098, GSK 2256098, GTPL7939, GTPL 7939, GTPL-7939, 1224887-10-8
Kusungunuka:Zosungunuka mu DMSO
Posungira:0 - 4 ° C kwa nthawi yochepa (masiku mpaka masabata), kapena -20 ° C kwa nthawi yaitali (miyezi).
Kufotokozera:
GSK2256098, yomwe imadziwikanso kuti GTPL7939, ndi focal adhesion kinase-1 (FAK) inhibitor yomwe imatha kukhala ndi antiangiogenic ndi antiantineoplastic. FAK inhibitor GSK2256098 imalepheretsa FAK, yomwe ingalepheretse kutsegulira kwa njira zingapo zotsatsira ma siginecha, kuphatikiza ERK, JNK/MAPK ndi PI3K/Akt, potero kuletsa kusamuka kwa chotupa, kuchulukana ndi kupulumuka, ndi chotupa angiogenesis. The tyrosine kinase FAK nthawi zambiri imayendetsedwa ndikumanga ma integrins mu extracellular matrix (ECM) koma imatha kuyendetsedwa ndi kukhazikitsidwa m'mitundu yosiyanasiyana yama cell chotupa.
Cholinga: FAK