MSC2530818

Isem Kimiku:

[(2S)-2-(4-Chlorophenyl)pyrrolidin-1-yl]-(3-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl)methanone

Kodiċi SMILES:

O=C(N1[C@H](C2=CC=C(Cl)C=C2)CCC1)C3=CN=C(NN=C4C)C4=C3

Kodiċi InChi:

InChI=1S/C18H17ClN4O/c1-11-15-9-13(10-20-17(15)22-21-11)18(24)23-8-2-3-16 (23)12-4-6-14(19)7-5-12/h4-7,9-10,16H,2-3,8H2,1H3,(H,20,21,22)/t16-/ m0/s1

InChi Key:

ODRITQGYYWHQGM-INIZCTEOSA-N

Keyword:

MSC2530818, MSC-2530818, MSC 2530818, 1883423-59-3

Solubilità:Solubbli fid-DMSO

Ħażna:0 - 4°C għal żmien qasir (jiem sa ġimgħat), jew -20°C għal żmien twil (xhur).

Deskrizzjoni:

MSC2530818 huwa Inibitur CDK8 Potenti, Selettiv, u Biodisponibbli Oralment b'CDK8 IC50 = 2.6 nM; Tbassir tal-PK tal-bniedem: Cl ~ 0.14 L/H/Kg; t1/2 ~ 2.4h; F > 75%. MSC2530818 juri selettività eċċellenti tal-kinase, qawwa bijokimika u ċellulari, stabbiltà mikrosomali, u huwa bijodisponibbli oralment. MSC2530818 juri qawwa u selettività xierqa għall-progress fi studji prekliniċi in vivo dwar l-effikaċja u s-sigurtà.

Mira: CDK