LDC000067

Ingoa matū:

3-[[6-(2-Methoxyphenyl)-4-pyrimidinyl]amino]benzenemethanesulfonamide

Waehere SMILES:

O=S(CC1=CC=CC(NC2=NC=NC(C3=CC=CC=C3OC)=C2)=C1)(N)=O

Waehere InChi:

InChI=1S/C18H18N4O3S/c1-25-17-8-3-2-7-15(17)16-10-18(21-12-20-16)22-14-6 -4-5-13(9-14)11-26(19,23)24/h2-10,12H,11H2,1H3,(H2,19,23,24)(H,20,21,22)

Kī InChi:

GGQCIOOSELPMBB-UHFFFAOYSA-N

Kupumatua:

LDC000067; LDC-000067; LDC 000067

Wairewa: 

Rokiroki: 

Whakaahuatanga:

Ko te LDC000067 he aukati CDK9 kaha me te whiriwhiri. Ko te LDC000067 i aukati i roto i te tuhi in vitro i roto i te ATP-whakataetae me te horopeta-whakawhirinaki. Ko te whakaaturanga whakaaturanga ira o nga pūtau i rongoahia ki te LDC000067 i whakaatu i te whakahekenga o nga mRNA poto poto, tae atu ki nga kaiwhakahaere nui o te tipu me te apoptosis. Ko te tātaritanga o te de novo RNA synthesis i kii i te whānuitanga pai o te CDK9. I te taumata ngota me te taumata pūtau, ka whakaputahia e LDC000067 nga ahuatanga o te aukati CDK9 penei i te whakaroa ake o te RNA polymerase II i runga i nga ira, me te mea nui, te whakaurunga o te apoptosis i roto i nga pūtau mate pukupuku. Ko te LDC000067 te aukati i te P-TEFb-whakawhirinaki i roto i te tuhinga in vitro. Ka whakakorikori i te apoptosis in vitro me in vivo me te BI 894999.

Whāinga: CDK9