CP-456773 konutai

Ingoa matū:

konutai ((1,2,3,5,6,7-hexahydro-s-indacen-4-yl)carbamoyl)((4-(2-hydroxypropan-2-yl)furan-2-yl)sulfonyl)amide

Waehere SMILES:

O=S(C1=CC(C(C)(O)C)=CO1)([N-]C(NC2=C3CCCC3=CC4=C2CCC4)=O)=O.[Na+]

Waehere InChi:

InChI=1S/C20H24N2O5S.Na/c1-20(2,24)14-10-17(27-11-14)28(25,26)22-19(23)21-18-15 -7-3-5-12(15)9-13-6-4-8-16(13)18;/h9-11,24H,3-8H2,1-2H3,(H2,21,22,23 );/q;+1/p-1

Kī InChi:

LFQQNXFKPNZRFT-UHFFFAOYSA-M

Kupumatua:

MCC950, MCC 950, MCC-950, CP-45677, CP45677, CP 45677, CRID-3, CRID3, CRID 3, CP-456773 konutai tote, Cytokine tuku tarukino aukati 3, 256373-96-3

Wairewa:Wairewa i roto i te DMSO

Rokiroki:0 - 4°C mo te wa poto (ra ki nga wiki), -20°C ranei mo te wa roa (marama).

Whakaahuatanga:

Ko te CP-456773, e mohiotia ana ko MCC950 me CRID3, he kaha me te whiriwhiri i te kaitautoko cytokine tuku me te NLRP3 inflammasome inhibitor mo te maimoatanga o nga mate pukupuku. Ko te CP-456773 te whakakore i te whakawhitinga o te interleukin 1β (IL-1β) me te tukatuka caspase 1. I aukati a MCC950 i te whakahohenga NLRP3 kano me te kore-kanoni i nga kuhanga nanomolar. Ko te MCC950 i aukati i te whakahohenga o te NLRP3 engari ehara i te AIM2, NLRC4, NLRP1 inflammasomes ranei. I whakaitihia e te MCC950 te hanga interleukin-1β (IL-1β) i roto i te vivo me te whakaheke i te kaha o te whakamatautau autoimmune encephalomyelitis (EAE), he tauira mate o te sclerosis maha. Ko te MCC950 he rongoa mo nga mate e pa ana ki te NLRP3, tae atu ki nga mate autoimmune me te autoimmune, me te taputapu mo te rangahau ano mo te NLRP3 inflammasome i roto i te hauora me te mate o te tangata.

Whainga: NLRP3