THZ531
Product Detail
Product Tags
| Pack Size | Availability | Pretium (USD) |
| 100mg | In Stock | 500 |
| 500mg | In Stock | 800 |
| 1g | In Stock | 1200 |
| Plus Sizes | Get Quotes | Get Quotes |
Nomen chemicum:
(R, E)-N-(4-(3-((5-chloro-4-(1H-indol-3-yl) pyrimidin-2-yl)amino)piperidine-1-carbonyl)phenyl)-4- (dimethylamino) sed-2-enamide
SMILES Code:
"O=C(NC1=CC=C(C(N2C[C@H])(NC3=NC=C(Cl)C(C4=CNC5=C4C=CC=C5)=N3)CCC2)=O)C= C1)/C=C/CN(C)C
InChi Code:
InChI=1S/C30H32ClN7O2/c1-37(2)15-6-10-27(39)34-21-13-11-20(12-14-21)29(40)38-16-5-7- 22(19-38)35-30-33-18-25(31)28(36-30)24-17-32-26-9-4-3-8-23(24)26/h3-4; 6,8-14,17-18,22,32H,5,7,15-16,19H2,1-2H3,(H,33,35,36)/b10-6+/ t22-/m1/s1
InChi Key:
RUBYHLPRZRMTJO-MOVYNIQHSA-N
Keyword:
THZ-531, THZ 531, THZ531, 1702809-17-3
Solubilitas:Solutum in DMSO
Repono:0 - 4°C ad terminum brevem (dies ad septimanas), vel -20°C ad terminum longi (menses).
Descriptio:
THZ531 est CDK12 covalens et inhibitor covalens CDK13. Cyclin-kinases dependentes 12 et 13 (CDK12 et CDK13) partes criticas in moderandis transscriptionibus gene. THZ531 irreversibiliter petant cysteinam extra kinasum dominium sitam. THZ531 damnum facit genei expressionis cum detrimento concursus elongationis et hyperphosphorylatae RNA polymerase II. THZ531 substantialiter diminuit expressionem DNA damna responsionis genesis et clavem factoris genesis transcriptionis super-consociatarum. THZ531 felis apoptoticum mortem cellae inducit. Moleculae parvae, quae specialiter CDK12 et CDK13 oppugnare possunt, ita auxilium cancrum cognoscendi subtypis adiuvant, quae praecipue ab actionibus kinasis dependentes sunt.
Target: CDK
