Riviciclib

Nomen chemicum:

2-(2-chlorophenyl) -5,7-dihydroxylum-8-((2R,3S)-2-(hydroxymethyl)-1-methylpyrrolidin-3-yl) -4H-chromenlum-4-unum hydrochloridum

SMILES Code:

O=C1C=C(C2=CC=CC=C2Cl)OC3=C1C(O)=CC(O)=C3[C@H]4[C@H](CO)N(C)CC4.[H] Cl

InChi Code:

InChI=1S/C21H20ClNO5.ClH/c1-23-7-6-12(14(23)10-24)19-15(25)8-16(26)20-17(27)9-18(28- 21(19)20)11-4-2-3-5-13(11)22;/h2-5,8-9,12,14,24-26H,6-7,10H2,1H3;1H/t12 -,14+;/m1./s1

InChi Key:

OOVTUOCTLAERQD-OJMBIDBESA-N

Keyword:

P276-00; P-276-00; P 276-00; P-27600; P 27600; P 27600; Riviciclib, Riviciclib HCl

Solubilitas: 

Repono: 

Descriptio:

Riviciclib, etiam P276-00 cognominatus, est flavonus et cyclinus kinasus dependens (CDK) inhibitor cum actione antineoplastica potentiale. P276-00 selective adstringit et vetat Cdk4/cyclinum D1, Cdk1/cyclinum B et Cdk9/cyclinum T1, serina/threonina kinases quae in moderandis cycli cellulis et multiplicatione cellularum functiones agunt. Inhibitio harum kinasium ducit ad comprehensionem cycli cellularum per transitum G1/S, inde inductionem apoptosis et inhibitionem tumoris cellulae multiplicationis.

Target: CDK