| CPDB0157 | BI-847325 | BI-847325 inhibitor kinase inhibitor dualis MEK/Aurora cum IC50 valores 3, 25, 15, 25, et 4 nM pro X laevis Aurora B, humana Aurora A et Aurora C, humana MEK1 et MEK2, respectively. Inhibere potest incrementum et salutem utriusque curationis rusticae et pharmacopolae resistentis melanomatis cellae lineae, expressionem MEK et Mcl-1 decrescentem, dum expressionem dapibus apoptoticis pro-apoptoticis augere. Ad 70 mg/kg, BI-847325 apoptosim inducit in curatione melanoma in vivo, simplicem et pharmacopolam repugnantem. |
