SEL120-34A

Nomen chemicum:

7,8-dibromo-9-methyl-2-piperazin-1-yl-5,6-dihydro-4H-imidazo[4,5,1-ij]quinoline hydrochloride

SMILES Code:

CC1=C(Br)C(Br)=C2CCCN3C2=C1N=C3N4CCNCC4.[H]Cl

InChi Code:

InChI=1S/C15H18Br2N4.ClH/c1-9-11(16)12(17)10-3-2-6-21-14(10)13(9)19-15(21)20-7-4- 18-5-8-20;/h18H,2-8H2,1H3;

InChi Key:

GQXLWUCQESKBSC-UHFFFAOYSA-N

Keyword:

SEL120-34A; SEL 120-34A; SEL-120-34A; SEL12034A; SEL 12034A; SEL-12034A

Solubilitas: 

Repono: 

Descriptio:

SEL120-34A potens et selectivus inhibitor CDK8 in AML cellulis activus est cum phosphorylatione serinarum STAT1 et STAT5 ditionum transactionis altae. EL120-34A vetat phosphorylationem STAT1 S727 et STAT5 S726 in cellulis cancri in vitro. Congruenter moderatio STATs- et NUP98-HOXA9 transcriptio dependens observata est ut dominans mechanismus actionis in vivo.

Target: CDK8